{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:39:19Z","timestamp":1788871159001,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Education, Science, and Technological Development of Serbia","award":["175011"],"award-info":[{"award-number":["175011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Recurrent aphthous ulcers (\n                      <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>\n                      ) represent a very common, but poorly understood mucosal disorder. The connection between immunity to cow's milk proteins (\n                      <jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>\n                      ) and oral diseases was noted earlier. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to goat's milk proteins (\n                      <jats:styled-content style=\"fixed-case\">GMP<\/jats:styled-content>\n                      ), by enzyme\u2010linked immunosorbent assay (\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      ) test, in subjects who have\n                      <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>\n                      and proven increased immunity to\n                      <jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty subjects with\n                      <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>\n                      (36 with proven increased immunity to\n                      <jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>\n                      and 14 without this increased immunity) were included in this research. Levels of serum\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gA,\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gG, and\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gE antibodies to the same quantity of the examined antigens were determined by\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      . The statistical analysis of data was performed by Wilcoxon rank\u2010sum test and\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      ann\u2013\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      hitney test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The levels of serum antifresh cow's milk\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gA,\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gG, and\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      gE antibodies were significantly higher than the levels of serum antifresh goat's milk, in subjects with\n                      <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>\n                      with proven increased immunoreactivity to\n                      <jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0003;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These results indicate that patients with\n                      <jats:styled-content style=\"fixed-case\">RAU<\/jats:styled-content>\n                      with increased immunity to\n                      <jats:styled-content style=\"fixed-case\">CMP<\/jats:styled-content>\n                      could consider the use of goat's milk as the alternative protein source.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12052","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T08:13:13Z","timestamp":1361779993000},"page":"523-527","source":"Crossref","is-referenced-by-count":5,"title":["Good tolerance to goat's milk in patients with recurrent aphthous ulcers with increased immunoreactivity to cow's milk proteins"],"prefix":"10.1111","volume":"42","author":[{"given":"Irina","family":"Besu","sequence":"first","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Clinic for Periodontology and Oral Medicine Faculty of Stomatology University of Belgrade Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Konic\u2010Ristic","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Metabolism Institute for Medical Research Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Damjanovic","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Besu","sequence":"additional","affiliation":[{"name":"Dental Ordination \u201cDr Besu\u201d Zrenjanin Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorica","family":"Juranic","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Radiology of Serbia Belgrade 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