{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:51:17Z","timestamp":1760298677482},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T00:00:00Z","timestamp":1361750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"(G. Marioni) from the University of Padova"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Angiogenin (<jats:styled-content style=\"fixed-case\">ANG<\/jats:styled-content>) is a member of the ribonuclease superfamily and of medical interest largely because it supports the growth of primary and metastatic malignancies. This study is the first to investigate the potential role of <jats:styled-content style=\"fixed-case\">ANG<\/jats:styled-content> in tongue carcinoma neo\u2010angiogenesis and cancer cell proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Angiogenin expression (in carcinoma cells and endothelial intratumor vessel cells), CD105\u2010assessed micro\u2010vessel density (MVD), and MIB\u20101 expression were correlated with prognostic parameters in 28 primarily consecutively operated <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>1\u2010T2 tongue carcinomas (squamous cell carcinoma [SCC]). Whenever feasible, a computer\u2010based image analysis system was used for the immunohistochemical reaction analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant correlations emerged between <jats:styled-content style=\"fixed-case\">ANG<\/jats:styled-content> expression in the tongue carcinoma cells or endothelial intratumor vessel cells and tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> recurrence rate or disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">ANG<\/jats:styled-content> expression was also unrelated to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105\u2010assessed <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 expression. Conversely, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105\u2010assessed <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> correlated directly with recurrence rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> was significantly shorter in cases with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105\u2010assessed <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> &gt;167\u00a0micro\u2010vessels\/mm<jats:sup>2<\/jats:sup> than in those with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105\u2010assessed <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> \u2264167\u00a0micro\u2010vessels\/mm<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results support the hypothesis that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>105\u2010assessed <jats:styled-content style=\"fixed-case\">MVD<\/jats:styled-content> would be a valuable parameter for predicting which patients with tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> are at greatest risk of disease recurrence. Despite our study results, the role of <jats:styled-content style=\"fixed-case\">ANG<\/jats:styled-content> in tongue carcinoma warrants further investigation in larger series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12053","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T08:16:39Z","timestamp":1361780199000},"page":"606-611","source":"Crossref","is-referenced-by-count":10,"title":["The role of angiogenin in pT1\u2010T2 tongue carcinoma neo\u2010angiogenesis and cell proliferation: an exploratory study"],"prefix":"10.1111","volume":"42","author":[{"given":"Gino","family":"Marioni","sequence":"first","affiliation":[{"name":"Department of Neurosciences Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Staffieri","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fasanaro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Stramare","sequence":"additional","affiliation":[{"name":"Department of Medicine Institute of Radiology University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bernardi","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Val","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Stellini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Odontostomatology Institute University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"de Filippis","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Blandamura","sequence":"additional","affiliation":[{"name":"Department of Medicine DIMED University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01995.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2008.00442.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03664.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.05.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206813"},{"key":"e_1_2_6_7_1","first-page":"7124","article-title":"Expression of angiopoietins and its clinical significance in non\u2010small cell lung cancer","volume":"62","author":"Tanaka F","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00888.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.08.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2007.0004"},{"key":"e_1_2_6_11_1","volume-title":"TNM classification of malignant tumors","author":"Sobin LH","year":"2009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606708103"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0962"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.06.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31824bb3ea"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500452558"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10040"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000224338.56902.28"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20546"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-2-18"}],"container-title":["Journal of Oral Pathology &amp; 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