{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:47:59Z","timestamp":1774712879821,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,3,17]],"date-time":"2013-03-17T00:00:00Z","timestamp":1363478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is an immune\u2010mediated mucocutaneous disease of uncertain aetiology. <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> has many manifestations: reticular, erosive, atrophic, plaque like, papular, bullous, with unique etiopathogenetic working. The purpose of this study is to find a link between different clinical types of lichen and the alterations of lymphocytes on peripheral blood and oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 21 patients were enrolled in this study. The mean age of patients was 53.82\u00a0years, between 31 and 78\u00a0years. <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> Diagnosis was afterwards confirmed by histopathology. Selected patients underwent to clinical evaluation, lesion characterization, incisional biopsy, samples histological analysis, peripheral blood collection. Blood specimens were submitted to cell count determination with differential, characterization of populations and circulating lymphocyte subpopulations using monoclonal antibodies in flow cytometry. Referring to the clinical presentation of lesions, patients were divided in two groups: red lesions (<jats:styled-content style=\"fixed-case\">RL<\/jats:styled-content>) and white lesions (<jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content>) and compared with an age\u2010matched control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of the immunophenotypic study showed correlation between <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> and the expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19 lymphocytes (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.693, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0005). The results of immunohistochemical study performed on histological specimens showed a significant correlation between <jats:styled-content style=\"fixed-case\">RL<\/jats:styled-content> group and expression of all lymphocyte tested (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.722 <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0002, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.579 <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0060, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.513 <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0173, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.548 <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We assume there is the responsibility of the expression of lymphocytes, not only type but also as quantity, in determining <jats:styled-content style=\"fixed-case\">RL<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">WL<\/jats:styled-content> manifestation of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Circulating lymphocytes may have a role, too.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12058","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T02:38:42Z","timestamp":1363574322000},"page":"642-647","source":"Crossref","is-referenced-by-count":19,"title":["A comparative immunohistochemical and immunophenotypical study on lymphocytes expression in patients affected by oral lichen planus"],"prefix":"10.1111","volume":"42","author":[{"given":"Guido","family":"Lorenzini","sequence":"first","affiliation":[{"name":"Tuscan School of Dental Medicine University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Viviano","sequence":"additional","affiliation":[{"name":"Tuscan School of Dental Medicine University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elettra","family":"Chisci","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Ferrara Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glauco","family":"Chisci","sequence":"additional","affiliation":[{"name":"Tuscan School of Dental Medicine University of Siena Siena Italy"},{"name":"Department of Maxillofacial Surgery University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Picciotti","sequence":"additional","affiliation":[{"name":"Tuscan School of Dental Medicine University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_3_1","first-page":"66","article-title":"Oral Lichen Planus: a review","volume":"74","author":"Anuradha Ch","year":"2008","journal-title":"NY State Dent J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962010000500010"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402004000100002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1983.tb01100.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1984.tb00792.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90244-4"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb01566.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00134.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1997.tb00453.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00788.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1987.tb00708.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.10.013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00820.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.09.075"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12058","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T14:10:16Z","timestamp":1696255816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,17]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/jop.12058"],"URL":"https:\/\/doi.org\/10.1111\/jop.12058","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,17]]}}}