{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:10:15Z","timestamp":1780485015854,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004508","name":"Prince of Songkla University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004508","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Objectives<\/jats:title>To determine (i) effects of lawsone methyl ether (LME<\/jats:styled-content>) mouthwash on antifungal drug resistance of oral C<\/jats:styled-content>andida<\/jats:italic>, (ii) effects of LME<\/jats:styled-content> mouthwash on changes in genotype of oral C<\/jats:styled-content>andida<\/jats:italic>, and (iii) allergy and subjects' satisfaction on LME<\/jats:styled-content> mouthwash in comparison with chlorhexidine (CHX<\/jats:styled-content>).<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>A randomized clinical trial was conducted in HIV<\/jats:styled-content>\u2010infected subjects and denture wearers receiving either LME<\/jats:styled-content> or CHX<\/jats:styled-content> mouthwash. Candidal culture by oral rinse technique was performed as baseline and after using the mouthwash for 2\u00a0weeks. Antifungal drug resistance and changes in genotype of oral C<\/jats:styled-content>andida<\/jats:italic> were assessed by microdilution assay, inverted repeat polymerase chain reaction and restriction fragment length polymorphism assays, respectively. Allergy and subjects' satisfaction on the mouthwashes were recorded. Statistical analysis was performed using C<\/jats:styled-content>hi\u2010squared and F<\/jats:styled-content>isher's exact tests.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010nine HIV<\/jats:styled-content>\u2010infected subjects (age range, 26\u201354\u00a0years; mean age, 41\u00a0years) and 38 denture wearers (age range, 27\u201376\u00a0years; mean age, 55\u00a0years) were enrolled. C<\/jats:styled-content>.\u00a0albicans<\/jats:italic> was the most common specie found in both groups followed by C<\/jats:styled-content>.\u00a0tropicalis<\/jats:italic>, C<\/jats:styled-content>.\u00a0parapsilosis, and C<\/jats:styled-content>.\u00a0glabrata<\/jats:italic>. Neither antifungal drug resistance nor significant changes in genotyping of C<\/jats:styled-content>andida<\/jats:italic> were noted among those receiving LME<\/jats:styled-content> mouthwash. Subjects' satisfaction on taste and smell of LME<\/jats:styled-content> mouthwash was comparable to that of CHX<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Use of LME<\/jats:styled-content> mouthwash for 2\u00a0weeks neither led to antifungal drug resistance nor significant changes in genotype of oral C<\/jats:styled-content>andida<\/jats:italic>. Thus, LME<\/jats:styled-content> may be an alternative mouthwash in prophylaxis of oral candidiasis among those at risk of developing the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12060","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T07:06:39Z","timestamp":1366095999000},"page":"698-704","source":"Crossref","is-referenced-by-count":24,"title":["Effects of lawsone methyl ether mouthwash on oral C<\/scp>andida<\/i> in HIV<\/scp>\u2010infected subjects and subjects with denture stomatitis"],"prefix":"10.1111","volume":"42","author":[{"given":"Wipawee","family":"Nittayananta","sequence":"first","affiliation":[{"name":"Prince of Songkla University Hat Yai Songkhla Thailand"},{"name":"Phytomedicine and Pharmaceutical Biotechnology Research Center Faculty of Pharmaceutical Sciences Prince of Songkla University Hat Yai Songkhla Thailand"},{"name":"Natural Product Research Center of Excellence Faculty of Science Prince of Songkla University Hat 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