{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T01:31:53Z","timestamp":1719192713565},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>is a major world health problem, which is progressing at an alarming rate. Lesions in the mouth and in other tissues and organs (oral and systemic lesions) in pediatric<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>infection are diverse and show differences in clinical presentation and severity from that of adults. Very little data exist for oral lesions in pediatric population in India. To assess oral mucosal status of<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected children and to correlate it with their salivary<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 150<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected children aged 6\u201318\u00a0years. They were divided into two groups. Group 1: Children prior to anti\u2010retroviral therapy, Group 2: Children undergoing anti\u2010retroviral therapy (for not more than 3\u00a0years). Criteria given by Ramos\u2010Gomez for diagnosis of oral lesions commonly associated with<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>infection in children were used to record the oral lesions. Salivary<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>levels were determined by enzyme\u2010linked immunosorbent assay. Data obtained were subjected to statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference in mean secretory<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>Ig<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) levels between the groups (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05). All the children had one or more oral mucosal lesions, with angular cheilitis being the most common lesion. There was a significant inverse relation between<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>levels and individual oral mucosal lesions (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.05). The number of oral lesions was inversely related to the<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral mucosal lesions were a significant feature of<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected infection, particularly in children prior to the onset of anti\u2010retroviral therapy. All children showed low<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>levels. Early recognition and management of oral conditions are important to improve the quality of life in these children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12061","type":"journal-article","created":{"date-parts":[[2013,3,30]],"date-time":"2013-03-30T03:17:40Z","timestamp":1364613460000},"page":"705-710","source":"Crossref","is-referenced-by-count":9,"title":["Oral mucosal status and salivary<scp>I<\/scp>g<scp>A<\/scp>levels of<scp>HIV<\/scp>\u2010infected children"],"prefix":"10.1111","volume":"42","author":[{"given":"Priya","family":"Subramaniam","sequence":"first","affiliation":[{"name":"The Oxford Dental College and Hospital Department of Pedodontics and Preventive Dentistry Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Kumar","sequence":"additional","affiliation":[{"name":"The Oxford Dental College and Hospital Department of Pedodontics and Preventive Dentistry Bangalore 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