{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:11:39Z","timestamp":1772665899147,"version":"3.50.1"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,10]],"date-time":"2013-06-10T00:00:00Z","timestamp":1370822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Background<\/jats:title>Apoptosis is a programme of cell death which does not induce an inflammatory response. Recent previous research has suggested a correlation between temporomandibular internal derangement and apoptosis. Fas ligand (FasL<\/jats:styled-content>) is an apoptosis\u2010inducing factor, known to trigger apoptosis through distinct signal pathways. This study aims to examine, by immunohistochemistry, the expression of FasL<\/jats:styled-content> in temporomandibular joint (TMJ<\/jats:styled-content>) articular discs of patients with anterior disc displacement with reduction (ADD<\/jats:styled-content>wR) and without reduction (ADD<\/jats:styled-content>woR) in patients with and without osteoarthrosis (OA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010two (n<\/jats:italic>\u00a0=\u00a042) TMJ<\/jats:styled-content> articular discs were divided into two cut\u2010offs: (i) 8 control, 17 ADD<\/jats:styled-content>wR, 17 ADD<\/jats:styled-content>woR, and (ii) without OA<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a025) and with OA<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a017). The area of immunostaining was compared statistically between groups (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec>Results<\/jats:title>Statistically significant differences were found in the expression of FasL<\/jats:styled-content> in TMJ<\/jats:styled-content> discs between the three groups (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001). ADD<\/jats:styled-content>wR<\/jats:styled-content> presented significant higher FasL<\/jats:styled-content> expression when compared with ADD<\/jats:styled-content>woR<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). Significant higher FasL<\/jats:styled-content> expression was observed in the group without OA<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001). All patients without OA<\/jats:styled-content> presented ADD<\/jats:styled-content>wR<\/jats:styled-content>, while all the patients with OA<\/jats:styled-content> presented ADD<\/jats:styled-content>woR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A higher area of in situ<\/jats:italic> immunostaining of FasL<\/jats:styled-content> was found in temporomandibular discs with reduction, which is the less severe condition. Moreover, a reduced expression of FasL<\/jats:styled-content> in the discs of patients with osteoarthrosis was found, suggesting that some aspects of apoptosis might underlie the progression of TMJ<\/jats:styled-content> disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12089","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T04:04:15Z","timestamp":1370923455000},"page":"69-75","source":"Crossref","is-referenced-by-count":10,"title":["FasL<\/scp> expression in articular discs of human temporomandibular joint and association with osteoarthrosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Flavio","family":"de Alc\u00e2ntara Camejo","sequence":"first","affiliation":[{"name":"School of Health and Biosciences Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR) Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Eduardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"School 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