{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:48:06Z","timestamp":1776134886164,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate whether the immunohistochemical expression of <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 is related to the diagnosis and pathogenesis of oral vascular lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Methods<\/jats:title><jats:p>Thirty cases each of pyogenic granuloma (<jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>) and hemangioma were studied. Antibodies against <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 were detected by immunoperoxidase staining in 3\u2010\u03bcm histological sections, and the results were analyzed qualitatively and quantitatively, respectively. Positive and negative cells were counted, and the mean number of positive cells was calculated for each case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial diagnosis of hemangioma was maintained in only 7 (23%) of the 30 cases studied, which were positive for <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101. The remaining 23 cases were reclassified as vascular malformation (<jats:styled-content style=\"fixed-case\">VM<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) and <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) due to the absence of staining. The endothelium of blood vessels was negative for <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>\u20101 in all cases initially diagnosed as <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a030). The percentage of <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1\u2010positive cells was higher in cases of <jats:styled-content style=\"fixed-case\">PG<\/jats:styled-content>, followed by hemangiomas and <jats:styled-content style=\"fixed-case\">VM<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Histological features are not sufficient to establish the correct diagnosis of oral hemangiomas, and an accurate anamnesis is essential in these cases. In addition, these findings demonstrate that vascular lesions express mediators of angiogenesis, <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1, and suggest that his process may play a role in the pathogenesis of vascular.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12092","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T03:55:50Z","timestamp":1370404550000},"page":"76-80","source":"Crossref","is-referenced-by-count":13,"title":["Study of the etiopathogenesis and differential diagnosis of oral vascular lesions by immunoexpression of <scp>GLUT<\/scp>\u20101 and <scp>HIF<\/scp>\u20101\u03b1"],"prefix":"10.1111","volume":"43","author":[{"given":"Denise H\u00e9len Imaculada Pereira","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Postgraduate Program Oral Pathology, Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9ricka Janine Dantas da","family":"Silveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program Oral Pathology, Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Miryam Costa","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Postgraduate Program Oral Pathology, Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pollianna Muniz","family":"Alves","sequence":"additional","affiliation":[{"name":"Dentistry State University of Para\u00edba Campina Grande PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia Maria Guedes","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Postgraduate Program Oral Pathology, Federal University of Rio Grande do Norte Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,4]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"EnjorasO WassefM ChapotR.Introduction: ISSVA Classification.Cambridge University Press. 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