{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:35:27Z","timestamp":1788870927281,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["FAPESP 2009\/53839-2"],"award-info":[{"award-number":["FAPESP 2009\/53839-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Background<\/jats:title>\n \n The histogenesis of neoplastic spindle cells of\n K<\/jats:styled-content>\n aposi's sarcoma is still uncertain, but some studies consider it a lymphatic vessel differentiation. Prox\u20101 is a nuclear transcription factor that plays a major role during embryonic lymphangiogenesis, and it has been considered a specific and sensitive lymphatic endothelial cell marker. The aim of this study was to determine the expression of\n P<\/jats:styled-content>\n rox\u20101 in oral\n K<\/jats:styled-content>\n aposi's sarcoma comparing the results with oral benign vascular tumors including capillary hemangiomas and pyogenic granulomas.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Expression of\n P<\/jats:styled-content>\n rox\u20101 and\n HHV<\/jats:styled-content>\n \u20108 was evaluated by immunohistochemistry in 30 oral\n K<\/jats:styled-content>\n aposi's sarcoma, 5 oral capillary hemangiomas, and 10 oral pyogenic granulomas. The labeling index was expressed as the percentage of positive cells for each case studied. Statistical comparison was performed using the\n W<\/jats:styled-content>\n ilcoxon\u2013\n M<\/jats:styled-content>\n ann\u2013\n W<\/jats:styled-content>\n hitney rank sum test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010eight (93.3%) and 30 oral\n K<\/jats:styled-content>\n aposi's sarcoma cases were positive for\n P<\/jats:styled-content>\n rox\u20101 and\n HHV<\/jats:styled-content>\n \u20108, respectively, while all oral benign vascular tumors were negative for these markers. The number of\n P<\/jats:styled-content>\n rox\u20101 and\n HHV<\/jats:styled-content>\n \u20108 oral\n K<\/jats:styled-content>\n aposi's sarcoma\u2010positive cells increased significantly from patch\/plaque to nodular histological stages.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The expression of\n P<\/jats:styled-content>\n rox\u20101 in the neoplastic spindle cells supports the view of a lymphatic differentiation in oral\n K<\/jats:styled-content>\n aposi's sarcoma. Prox\u20101 may also be involved in the pathogenesis of oral\n K<\/jats:styled-content>\n aposi's sarcoma as the number of positive spindle cells increased progressively from patch to nodular stages and could be eventually useful as an additional diagnostic tool for differential diagnosis between oral\n K<\/jats:styled-content>\n aposi's sarcoma and benign oral vascular lesions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12097","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T21:58:47Z","timestamp":1371160727000},"page":"132-136","source":"Crossref","is-referenced-by-count":12,"title":["Expression of\n PROX<\/scp>\n \u20101 in oral\n K<\/scp>\n aposi's sarcoma spindle cells"],"prefix":"10.1111","volume":"43","author":[{"given":"Bruno Augusto","family":"Benevenuto de Andrade","sequence":"first","affiliation":[{"name":"Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velia","family":"Ram\u00edrez\u2010Amador","sequence":"additional","affiliation":[{"name":"Department of Health Care Universidad Aut\u00f3noma Metropolitana Xochimilco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Anaya\u2010Saavedra","sequence":"additional","affiliation":[{"name":"Department of Health Care Universidad Aut\u00f3noma Metropolitana Xochimilco M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mart\u00ednez\u2010Mata","sequence":"additional","affiliation":[{"name":"Dentistry School Universidad Aut\u00f3noma de Chihuahua Chihuahua M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe P.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard","family":"Graner","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oslei","family":"Paes de Almeida","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas (UNICAMP) Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.08.015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00740.x"},{"key":"e_1_2_5_4_1","first-page":"294","article-title":"Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium","volume":"119","author":"Beckstead JH","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1383"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1384"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21969"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880033"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.07.008"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-001-0214-9"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21024"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81511-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.7.1505"},{"key":"e_1_2_5_14_1","first-page":"170","volume-title":"World Health Organization Classification of tumours. 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