{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:37:50Z","timestamp":1762623470611,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"MEXT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"KAKENHI","doi-asserted-by":"crossref","award":["20791239"],"award-info":[{"award-number":["20791239"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dry mouth is a common complaint in patients undergoing radiotherapy. Here, we employed the oral moisture meter Mucus <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> to evaluate dry mouth in head and neck tumor patients before and after they underwent radiotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 17 newly diagnosed patients with pharyngeal squamous cell carcinoma or unknown primary squamous cell carcinoma, who received head and neck radiation therapy at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>okyo <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in 2008\u20132010. The primary sites were the epipharynx (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), oropharynx (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), or hypopharynx (<jats:italic>n<\/jats:italic>\u00a0=\u00a05); it was unknown in five cases. Salivary function was assessed by a dry mouth questionnaire, resting saliva test, chewing gum test, and Mucus <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, before (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), immediately after radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a010), and at 3 (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) and 12\u00a0months after radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The questionnaire, resting saliva test, and chewing gum test at 3 and 12\u00a0months after radiotherapy indicated a significantly decreased resting and stimulated whole saliva flow rate than prior radiotherapy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In contrast, Mucus <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> results showed significant worsening of xerostomia at 12\u00a0months after radiotherapy (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mucus <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> has been proven to be an objective diagnostic tool for patients with serious dry mouth, such as in patients with <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>jogren's syndrome. However, we did not find a perfect correlation between Mucus <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and other objective (resting saliva and chewing gum) and subjective (questionnaire) measures of dry mouth. To precisely diagnose radiotherapy\u2010induced dry mouth, further improvement to the method is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12099","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T07:23:04Z","timestamp":1371453784000},"page":"97-102","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010invasive objective evaluation of radiotherapy\u2010induced dry mouth"],"prefix":"10.1111","volume":"43","author":[{"given":"Youko","family":"Fujimaki","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Graduate School of Medicine University of Tokyo Tokyo Japan"},{"name":"Department of Artificial Organs and Otolaryngology National Institute of Sensory Organs Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Artificial Organs and Otolaryngology National Institute of Sensory Organs Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Ichi","family":"Ishimoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Social Insurance Central General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Social Insurance Central General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Igaki","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuro","family":"Terahara","sequence":"additional","affiliation":[{"name":"Department of Radiology Toho University Omori Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Asakage","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tastuya","family":"Yamasoba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Faculty of Medicine Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"6","article-title":"Evaluation, differential diagnosis, and treatment of xerostomia","volume":"61","author":"Daniels TE","year":"2000","journal-title":"J Rheumatol Suppl"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/19424396.2000.12223142","article-title":"Xerostomia \u2013 clinical evaluation and treatment in general practice","volume":"28","author":"Daniels TE","year":"2000","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_5_4_1","first-page":"841","article-title":"Hyposalivation in elderly patients","volume":"72","author":"Guputa A","year":"2006","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20045"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/66754762"},{"key":"e_1_2_5_8_1","first-page":"214","article-title":"Xerostomia after radiotherapy and its effect on quality of life in head and neck cancer patients","volume":"15","author":"Kakoei S","year":"2012","journal-title":"Arch Iran Med"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22302"},{"key":"e_1_2_5_10_1","first-page":"569327","article-title":"Effects of chewing different flavored gums on salivary flow rate and pH","volume":"2012","author":"Nogourani MK","year":"2012","journal-title":"Int J Dent"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359109005919"},{"key":"e_1_2_5_12_1","first-page":"153","article-title":"Comparison between saliva stimulants and saliva substitutes in patients with symptoms related to dry mouth. 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