{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:36:27Z","timestamp":1791311787572,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Background<\/jats:title>Recurrent aphthous stomatitis (RAS<\/jats:styled-content>) is a common oral ulcerative condition. At ulcer sites vascular adhesion molecule\u20101 (VCAM<\/jats:styled-content>\u20101), E<\/jats:styled-content>\u2010selectin and intercellular adhesion molecule\u20101 (ICAM<\/jats:styled-content>\u20101) are strongly expressed on blood vessels, and ICAM<\/jats:styled-content>\u20101 is expressed on keratinocytes. Expression of these molecules would promote leukocyte accumulation and invasion of the epithelium. Thus, polymorphisms in these candidate genes might contribute to RAS<\/jats:styled-content> susceptibility. We investigated whether the inheritance of specific selectin, ICAM<\/jats:styled-content> and VCAM<\/jats:styled-content> gene polymorphisms is associated with RAS<\/jats:styled-content> susceptibility.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ninety\u2010six RAS<\/jats:styled-content> cases and 153 controls were recruited from a J<\/jats:styled-content>ordanian population. Blood was collected for hematological investigations and genotyping. Six SNP<\/jats:styled-content>s were genotyped: E<\/jats:styled-content>\u2010selectin rs5361 and rs1805193, L<\/jats:styled-content>\u2010selectin, rs2205849, ICAM<\/jats:styled-content>\u20101 rs5498, ICAM<\/jats:styled-content>\u20105 rs885743 and VCAM<\/jats:styled-content>\u20101 rs1800821. Association was determined using chi\u2010square and binary logistic regression analysis after correcting for confounding factors. Linkage disequilibrium was determined using the EH<\/jats:styled-content> program, and the Phase 2.1 program was used to construct and compare haplotypes between cases and controls.<\/jats:p><\/jats:sec>Results<\/jats:title>There was a significant association of the A<\/jats:styled-content> allele (P<\/jats:italic>corr<\/jats:sub>\u00a0=\u00a00.027), AA<\/jats:styled-content> and AC<\/jats:styled-content> genotypes (OR<\/jats:styled-content>\u00a0=\u00a010.9 and 9.0, respectively) of the E<\/jats:styled-content>\u2010selectin rs5361 gene polymorphism and TAA<\/jats:styled-content> haplotype (rs2205849, rs5361, and rs1805193, respectively; P<\/jats:italic>\u00a0=\u00a00.03) with RAS<\/jats:styled-content>. None of the other SNP<\/jats:styled-content>s showed a significant association.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This is the first report to link inheritance of the A<\/jats:styled-content> allele, AA<\/jats:styled-content> and AC<\/jats:styled-content> genotypes of the E<\/jats:styled-content>\u2010selectin rs5361 polymorphism with increased risk of RAS<\/jats:styled-content>. Further studies in different patient cohorts are needed to confirm the association, and functional analyses might clarify the biological significance of the association.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12100","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T06:48:24Z","timestamp":1371538104000},"page":"741-746","source":"Crossref","is-referenced-by-count":13,"title":["Association of cell adhesion molecule gene polymorphisms with recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"42","author":[{"given":"Asem","family":"Alkhateeb","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Genetics Jordan University of Science and Technology (JUST) Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Karasneh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery JUST Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebah","family":"Abbadi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Genetics Jordan University of Science and Technology (JUST) Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis College of Dentistry Al Mustansiriya University Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Thornhill","sequence":"additional","affiliation":[{"name":"Unit of Oral and Maxillofacial Medicine and Surgery School of Clinical Dentistry The University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e33"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01324.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90211-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00089.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.827"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.4049\/jimmunol.145.3.865","article-title":"IL\u20104 regulates endothelial cell activation by IL\u20101, TNF or IFN\u2010gamma","volume":"145","author":"Thornhill MH","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.4049\/jimmunol.144.7.2558","article-title":"A 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