{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:43:08Z","timestamp":1732034588451},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to compare between three possible osteoporotic treatments in prevention of glucocorticoid\u2010induced alveolar bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty adult female Wistar rats with an average weight 150\u2013200\u00a0g were randomized into five groups: group I (control) was intraperitoneally injected with saline. The other experimental groups (<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>&amp;<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>&amp; V) were intraperitoneally injected with 200\u00a0\u00b5g\/100\u00a0g body weight dexamethasone. The experimental groups<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>and V received intraperitoneal injection of 10\u00a0mg\/kg\/day pheniramine maleate (H1 receptor antagonist), ranitidine hydrochloride (H2 receptor antagonist) and concomitant doses of both H1 &amp; H2 receptor antagonists respectively. After 30\u00a0days, the rats have been sacrificed. The mandibles were examined histologically, histochemically and histomorphometrically. The bone mineral density was measured using dual\u2010energy X\u2010ray absorptiometry (<jats:styled-content style=\"fixed-case\">DEXA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathologically the glucocorticoid group showed wide medullary cavities with wide osteocytic lacunae. These marrow cavities were reduced in the prophylactic groups (III, IV) but increased in group V. Bone histomorphometric analysis revealed improvement in static bone parameters in groups III and IV and deterioration in group V in comparison to group II. The<jats:styled-content style=\"fixed-case\">DEXA<\/jats:styled-content>revealed significant reduction in the bone mineral density in all experimental groups compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a rat model, the administration of<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1 or<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>2 receptor antagonists separately could minimize the alveolar bone loss caused by the administration of glucocorticoids while concomitant administration of both<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>1 and<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>2 receptor antagonists deteriorated the bone condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12104","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T05:51:52Z","timestamp":1373608312000},"page":"148-156","source":"Crossref","is-referenced-by-count":6,"title":["The ability of<scp>H<\/scp><sub>1<\/sub>or<scp>H<\/scp><sub>2<\/sub>receptor antagonists or their combination in counteracting the glucocorticoid\u2010induced alveolar bone loss in rats"],"prefix":"10.1111","volume":"43","author":[{"given":"Bassant A.","family":"Ezzat","sequence":"first","affiliation":[{"name":"Department of Oral Biology Faculty of Oral and Dental Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa M.S.","family":"Abbass","sequence":"additional","affiliation":[{"name":"Department of Oral Biology Faculty of Oral and Dental Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611435200"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050541"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/154.2_Pt_2.S28"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2007.05.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1557(200005\/06)9:3<187::AID-PDS494>3.0.CO;2-J"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01754.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.1.66"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010007108155"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0990"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2004.06.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(199701)64:1<128::AID-JCB15>3.0.CO;2-H"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/236385a0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/302832a0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(87)90102-2"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.2.E141"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.07.026"},{"key":"e_1_2_6_20_1","first-page":"281","article-title":"Bone mastocytosis. 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