{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:28:48Z","timestamp":1790166528680,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate salivary markers related to burning mouth syndrome (<jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A cross\u2010sectional prospective controlled clinical study of 58 patients (28 <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> and 30 control). The presence of mineral and trace metals in unstimulated whole saliva was analyzed in <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients and in control subjects by means of <jats:styled-content style=\"fixed-case\">ICP<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">OES<\/jats:styled-content>. The parameters analyzed were as follows: oral health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014) and the Hospital Anxiety Depression (<jats:styled-content style=\"fixed-case\">HAD<\/jats:styled-content>) scale. A visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) was used to measure the intensity of burning sensation (pain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean pain value for patients with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> was 7.8\u00a0\u00b1\u00a02.4. <jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014 oral health\u2010related quality of life among <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients was found to be affected: total <jats:styled-content style=\"fixed-case\">BMS OHIP<\/jats:styled-content>\u201014 (16.98\u00a0\u00b1\u00a012.29) vs. control (8.53\u00a0\u00b1\u00a010.5) with significant difference (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.015). Concentrations of the different elements were slightly higher among <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients but without statistically significant differences for any of the elements analyzed (Na, K, Ca, Mg, Fe, Cu, Mn, Zn, B, P, S, Al, Pb, Cd, Cr, Ni, As, Be, Bi, Co, Li, Mo, Sb, Se, Sr, Ti, Tl, V).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study failed to identify abnormal levels of minerals or trace elements in saliva of patients with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12105","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T11:17:25Z","timestamp":1374232645000},"page":"111-116","source":"Crossref","is-referenced-by-count":24,"title":["Mineral and trace element analysis of saliva from patients with <scp>BMS<\/scp>: a cross\u2010sectional prospective controlled clinical 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