{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:51:35Z","timestamp":1769763095379,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIAMS R01 AR051989"],"award-info":[{"award-number":["NIAMS R01 AR051989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to characterize the contralateral non\u2010surgical temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) in mice that had an opposing osteoarthrosis(<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>)\u2010like joint induced by unilateral partial discectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s on one side in mice were subjected to partial discectomy. Both surgical and contralateral non\u2010surgical <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s were collected at 4, 8, 12 and 16\u00a0weeks post\u2010surgery for histological examination. The morphology of the articular cartilage of the condyle was evaluated using a scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A progression of articular cartilage degeneration was seen in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s following unilateral partial discectomy, including increased proteoglycan staining in the extracellular matrix at 4\u00a0weeks, the appearance of chondrocyte clusters at 8\u00a0weeks, reduced proteoglycan staining and fibrillation at 12\u00a0weeks and the loss of articular cartilage at 16\u00a0weeks. In the contralateral non\u2010surgical <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s, increased proteoglycan staining occurred in the articular cartilage of the condyle at 8\u00a0weeks and continued to age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The result indicated that <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>\u2010like changes in one <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> by partial discectomy could initiate early\u2010onset articular cartilage degeneration in the contralateral non\u2010surgical <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> in mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12113","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T09:55:53Z","timestamp":1379498153000},"page":"162-165","source":"Crossref","is-referenced-by-count":28,"title":["Articular cartilage degeneration in the contralateral non\u2010surgical temporomandibular joint in mice with a unilateral partial discectomy"],"prefix":"10.1111","volume":"43","author":[{"given":"Wendy A.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Servais","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Polur","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yefu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"},{"name":"Faculty of Medicine Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"},{"name":"Faculty of Medicine Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(86)80075-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.10.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700406"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.01.002"},{"key":"e_1_2_6_6_1","volume-title":"Management of temporomandibular disorders and occlusion","author":"Okeson JP","year":"2012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.1999.0193"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.04.023"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7152.190"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-005-0056-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.10.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512453324"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2003.50133"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90109-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0272"}],"container-title":["Journal of Oral Pathology &amp; 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