{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:50:13Z","timestamp":1760100613201},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Higher Education, Scientific Research, and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Altered activity of DNA<\/jats:styled-content> repair enzymes may be involved in modulating cancer susceptibility and pathogenesis of head and neck cancer (HNC<\/jats:styled-content>). We conducted a case\u2013control study to test the association between three common single\u2010nucleotide polymorphisms of XRCC<\/jats:styled-content>1, ERCC<\/jats:styled-content>2,<\/jats:italic> and ERCC<\/jats:styled-content>3<\/jats:italic> genes with HNC<\/jats:styled-content> risk in Tunisian patients. To the best of our knowle dge, this is the first report on polymorphisms in XRCC<\/jats:styled-content>1, ERCC<\/jats:styled-content>2,<\/jats:italic> and ERCC<\/jats:styled-content>3<\/jats:italic> and susceptibility to HNC<\/jats:styled-content> in our population. The genotype analyses of XRCC<\/jats:styled-content>1 <\/jats:italic>A<\/jats:styled-content>rg399G<\/jats:styled-content>ln, ERCC<\/jats:styled-content>2 <\/jats:italic>L<\/jats:styled-content>ys751G<\/jats:styled-content>ln, and ERCC<\/jats:styled-content>3<\/jats:italic> 7122 A<\/jats:styled-content>>G<\/jats:styled-content> polymorphisms for 169 HNC<\/jats:styled-content> patients, and 261 controls were performed using the PCR<\/jats:styled-content>\u2010based restriction fragment length polymorphism. Stratification of the populations according to smoking and drinking habits and occupational exposure highlighted the importance of tobacco, alcohol, and toxic substance as three risk co\u2010factors for the development of HNC<\/jats:styled-content>. Our study suggests that only the XRCC<\/jats:styled-content>1 <\/jats:italic>A<\/jats:styled-content>rg399G<\/jats:styled-content>ln polymorphism was associated with the risk of HNC<\/jats:styled-content> in the Tunisian population (OR<\/jats:styled-content>\u00a0=\u00a02.04; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001). Furthermore, the risk of HNC<\/jats:styled-content> was associated with XRCC<\/jats:styled-content>1 <\/jats:italic>A<\/jats:styled-content>rg399G<\/jats:styled-content>ln polymorphism stratified by occupational exposure status (OR<\/jats:styled-content>\u00a0=\u00a02.29; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.024). However, no statistically significant association was observed between the risk of developing HNC<\/jats:styled-content> and the ERCC<\/jats:styled-content>2 Lys751Gln and ERCC<\/jats:styled-content>3 A<\/jats:styled-content>>G<\/jats:styled-content> polymorphisms. These data suggest that the XRCC<\/jats:styled-content>1 <\/jats:italic>A<\/jats:styled-content>rg399G<\/jats:styled-content>ln polymorphism is associated with an increased risk of developing HNC<\/jats:styled-content>, because it correlates with occupational exposure in T<\/jats:styled-content>unisian population.<\/jats:p>","DOI":"10.1111\/jop.12114","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T12:53:33Z","timestamp":1378904013000},"page":"217-224","source":"Crossref","is-referenced-by-count":14,"title":["DNA<\/scp> repair gene polymorphisms and risk of head and neck cancer in the T<\/scp>unisian population"],"prefix":"10.1111","volume":"43","author":[{"given":"Rim","family":"Khlifi","sequence":"first","affiliation":[{"name":"Marine Ecotoxicology UR 09\u201003 Sfax University IPEIS Sfax Tunisia"},{"name":"Bioinformatics Unit Centre of Biotechnology of Sfax Sfax 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