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However, the mechanisms underlying the effect of Cetuximab in human oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) remain unclear. Here, we report that Cetuximab modulates <jats:styled-content style=\"fixed-case\">EGFR<\/jats:styled-content> protein stability through the ubiquitin\/proteasome pathway, resulting in the inhibition of human <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> growth. Cetuximab significantly inhibited the migration and invasion of human <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> cells by blocking epithelial\/mesenchymal transition (<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>) and the <jats:styled-content style=\"fixed-case\">AKT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content> pathways. Furthermore, Cetuximab\u2010inhibited cell growth by modulating the expression of integrin \u03b25. Taken together, these results provide novel insights into the mechanism of Cetuximab action and suggest potential therapeutic strategies for <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jop.12116","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T12:54:07Z","timestamp":1378904047000},"page":"250-257","source":"Crossref","is-referenced-by-count":32,"title":["Cetuximab inhibits oral squamous cell carcinoma invasion and metastasis via degradation of epidermal growth factor receptor"],"prefix":"10.1111","volume":"43","author":[{"given":"Wei","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Oromaxillofacial\u2010Head and Neck Surgery School of Stomatology China Medical University Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Key Laboratory of 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