{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:00:36Z","timestamp":1785420036069,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Background<\/jats:title>Cancer cannibalism is used to differentiate benign tumors from malignant, but recently the phenomenon has been demonstrated in giant cell tumor of tendon sheath (localized type). Microscopically and pathogenetically, this tumor is similar to central giant cell granuloma (CGCG<\/jats:styled-content>) and peripheral giant cell granuloma (PGCG<\/jats:styled-content>) of oral cavity. Hence, attempt has been made to study the cannibalistic giant cells (GC<\/jats:styled-content>s) in CGCG<\/jats:styled-content> and PGCG<\/jats:styled-content> with their correlation with the biological behavior.<\/jats:p><\/jats:sec>Methods<\/jats:title>Surgically treated 16 CGCG<\/jats:styled-content> and 23 PGCG<\/jats:styled-content> cases with adequate clinical and radiographic documentation were selected. Quantification of cannibalistic GC<\/jats:styled-content>s was performed using routine HE<\/jats:styled-content> stain. Hundred GC<\/jats:styled-content>s were examined in each section, and number of cannibalistic cells was expressed in percentage. Ten cases were randomly selected for further immunohistochemical analysis with CD<\/jats:styled-content>68 and bcl\u20102.<\/jats:p><\/jats:sec>Results<\/jats:title>Cannibalism was found in all the cases (100%). The frequency of occurrence of cannibalistic GC<\/jats:styled-content>s ranged from 20% to 56% with a mean of 33.62\u00a0\u00b1\u00a08.9. CGCG<\/jats:styled-content> showed significantly higher mean cannibalistic GC<\/jats:styled-content> frequency (38.06\u00a0\u00b1\u00a010.15) than PGCG<\/jats:styled-content> (30.04\u00a0\u00b1\u00a05.63). In aggressive CGCG<\/jats:styled-content>, mean cannibalistic GC<\/jats:styled-content> frequency was significantly higher (42.20\u00a0\u00b1\u00a010.4) than non\u2010aggressive type (31.17\u00a0\u00b1\u00a06.014). Similarly, recurrent cases showed significantly higher mean cannibalistic cell frequency (43\u00a0\u00b1\u00a06.26) than non\u2010recurrent cases (30.81\u00a0\u00b1\u00a06.66). Immunohistochemistry results showed histiocytic nature of GC<\/jats:styled-content>s as well as mononuclear cells. The internalized cells did not expressed bcl\u20102, suggesting that the internalization induces apoptotic cell death.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Assessment of frequency of cannibalistic cells in CGCG<\/jats:styled-content> and PCGC<\/jats:styled-content> could help in predicting the biological behavior of the tumor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12119","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T23:37:35Z","timestamp":1381534655000},"page":"459-463","source":"Crossref","is-referenced-by-count":31,"title":["Cellular cannibalism in central and peripheral giant cell granuloma of the oral cavity can predict biological behavior of the lesion"],"prefix":"10.1111","volume":"43","author":[{"given":"Sachin C.","family":"Sarode","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Dr. D. Y. Patil Dental College and Hospital Dr. D.Y. Patil Vidyapeeth Pimpri Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi S.","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Dr. D. Y. Patil Dental College and Hospital Dr. D.Y. Patil Vidyapeeth Pimpri Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"92","article-title":"The bird's eye cell: cannibalism or abnormal division of tumor cells","volume":"25","author":"Bauchwitz MA","year":"1981","journal-title":"Acta Cytol"},{"key":"e_1_2_6_3_1","first-page":"30","article-title":"Absence of prognostic features in the cytology of effusions due to mammary cancer","volume":"23","author":"Towers KH","year":"1979","journal-title":"Acta Cytol"},{"key":"e_1_2_6_4_1","first-page":"293","article-title":"Giant\u2010cell carcinoma of the lung. 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