{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:42:52Z","timestamp":1782754972066,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"crossref","award":["No.545\/165\/1432"],"award-info":[{"award-number":["No.545\/165\/1432"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy, and safety of newly customized natural oral mucoadhesive gels, containing either aloe vera or myrrh as active ingredients, in the management of minor recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Ninety subjects with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> were recruited from <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ral <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicine <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic, at <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>aculty of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>entistry, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ing Abdulaziz <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>audi <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rabia, for this randomized, double\u2010blind, placebo\u2010controlled study. Two new natural gels, containing aloe vera and myrrh, were prepared in a concentration of (0.5% w\/w), in addition to a plain mucoadhesive gel used as a placebo. Patients with fresh ulcers (&lt;48\u2010h duration) were instructed to apply either one of the three gels four times a day for a period of 5\u00a0days. Clinical efficacy was investigated in the form of changes in ulcer size, pain intensity, erythema, and exudation at days 4 and 6 of study entry. Participants were interviewed for the emergence of any side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>76.6% of patients using aloe gel showed complete ulcer healing, 86.7%, and 80% of them revealed subsidence of erythema and exudation, respectively, especially at day 6 visit, whereas 76.7% of myrrh\u2010treated patients revealed almost absence of pain at day 6. No side effects were encountered with the use of any of the three gels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new formulated aloe\u2010 and myrrh\u2010based gels proved to be effective in topical management of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. Aloe was superior in decreasing ulcer size, erythema, and exudation; whereas myrrh resulted in more pain reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12130","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T10:52:27Z","timestamp":1382698347000},"page":"405-409","source":"Crossref","is-referenced-by-count":70,"title":["Clinical efficacy of new aloe vera\u2010 and myrrh\u2010based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double\u2010blind, vehicle\u2010controlled study"],"prefix":"10.1111","volume":"43","author":[{"given":"Ghada","family":"Mansour","sequence":"first","affiliation":[{"name":"Department of Oral Basic and Clinical Sciences Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Department of Oral Medicine Periodontology Oral Diagnosis and Oral Radiology Faculty of Dentistry Alexandria University Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soliman","family":"Ouda","sequence":"additional","affiliation":[{"name":"Department of Oral Basic and Clinical Sciences Faculty of Dentistry King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam M.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Natural Products and Alternative Medicine Faculty of Pharmacy King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Department of Pharmacognosy Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01134.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01840.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02393.x"},{"key":"e_1_2_5_5_1","first-page":"29","article-title":"Buccoadhesive drug delivery system: need","volume":"2","author":"Lokhande SS","year":"2012","journal-title":"Asian J Biomed Pharm Sci"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jcdp-9-3-88","article-title":"Review of over\u2010the\u2010counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing Glycyrrhiza complex herbal extract","volume":"9","author":"Burgess J","year":"2008","journal-title":"J Contemp Dent Pract"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3182171164"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.106905"},{"key":"e_1_2_5_9_1","first-page":"763","article-title":"An update review on Commiphora molmol and related species","volume":"38","author":"Tonkal AM","year":"2008","journal-title":"J Egyp Soc Parasitol"},{"key":"e_1_2_5_10_1","first-page":"379","volume-title":"Natural therapeutics pocket guide","author":"Krinsky DL","year":"2003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.12.014"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770130405"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80164-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.105237"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)00112-8"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13081599"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCIDEN.S24064"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/15476910903409835"},{"key":"e_1_2_5_19_1","first-page":"130","article-title":"Effects of myrrh extract on proliferation and collagen mRNA expression of human fibroblasts in vitro","volume":"28","author":"Bai XZ","year":"2012","journal-title":"Zhonghua Shao Shang Za Zhi"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9601519"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.44785"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/278718"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/379029a0"},{"key":"e_1_2_5_24_1","first-page":"238","article-title":"Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study","volume":"57","author":"George D","year":"2009","journal-title":"Gen Dent"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.025"}],"container-title":["Journal of Oral Pathology &amp; 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