{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:19:10Z","timestamp":1767899950078,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIAMS R01 AR051989"],"award-info":[{"award-number":["NIAMS R01 AR051989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether reduction of the discoidin domain receptor 2 (Ddr2) delays the progression of condylar cartilage degeneration in the temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) of mouse models with osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Double\u2010heterozygous (<jats:italic>Col11a1<\/jats:italic>\u2010 and <jats:italic>Ddr2<\/jats:italic>\u2010haploinsufficiency, <jats:italic>Col11a1<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>;<jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>) mice were generated. <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>s of <jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice were subjected to partial discectomy. Condylar cartilage from the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> of <jats:italic>Col11a1<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>;<jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice, surgically treated (discectomy) <jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice, and their corresponding controls was characterized by means of histology and evaluated using a scoring system specific to mouse joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The progression of condylar cartilage degeneration was significantly delayed in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> of <jats:italic>Col11a1<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup>;<jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice compared with those of the <jats:italic>Col11a1<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice. The progression of condylar cartilage degeneration in the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> of <jats:italic>Ddr2<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice following discectomy was also significantly delayed when compared with their wild\u2010type littermates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced expression of Ddr2 delays the progression of condylar cartilage degeneration, induced either by type <jats:styled-content style=\"fixed-case\">XI<\/jats:styled-content> collagen haploinsufficiency or by a partial discectomy, in <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12137","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T10:52:39Z","timestamp":1384253559000},"page":"317-321","source":"Crossref","is-referenced-by-count":8,"title":["Delayed progression of condylar cartilage degeneration, by reduction of the discoidin domain receptor 2, in the temporomandibular joints of osteoarthritic mouse models"],"prefix":"10.1111","volume":"43","author":[{"given":"Armando","family":"Salazar","sequence":"first","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Polur","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Servais","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yefu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"},{"name":"Faculty of Medicine Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston MA USA"},{"name":"Faculty of Medicine Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-005-0056-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700406"},{"key":"e_1_2_6_4_1","first-page":"237","article-title":"A cross\u2010sectional and longitudinal study of craniomandibular dysfunction in an elderly population","volume":"6","author":"Osterberg T","year":"1992","journal-title":"J Craniomandib Disord"},{"key":"e_1_2_6_5_1","first-page":"2731","article-title":"NEP: a novel receptor\u2010like tyrosine kinase expressed in proliferating neuroepithelia","volume":"8","author":"Zerlin M","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.09.089"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709290200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.10.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27582"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11233"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.01.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.025"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1997.19110001.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500361200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22876"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.11.008"}],"container-title":["Journal of Oral Pathology &amp; 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