{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:53:30Z","timestamp":1765976010277,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81071266","30901683"],"award-info":[{"award-number":["81071266","30901683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Independent Research Project for Postgraduates of Wuhan University","award":["201130402020010"],"award-info":[{"award-number":["201130402020010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Background<\/jats:title>Synovial chondromatosis (SC<\/jats:styled-content>) of temporomandibular joint (TMJ<\/jats:styled-content>) is a rare proliferative disorder characterized by the formation of cartilaginous or osteocartilaginous nodules in synovium and joint space. Fibroblast growth factor 2 (FGF<\/jats:styled-content>\u20102) is frequently applied in chondrogenic differentiation assays. Therefore, we hypothesized that FGF<\/jats:styled-content>\u20102 might involved in the pathogenesis of SC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>SC<\/jats:styled-content> synovium and loose bodies (LB<\/jats:styled-content>s) specimens were observed by histological and immunohistochemical methods. Real\u2010time PCR<\/jats:styled-content> was conducted for comparing genes expressions in SC<\/jats:styled-content> and normal synovium. SC<\/jats:styled-content> synoviocytes were stimulated by FGF<\/jats:styled-content>\u20102 in the presence or absence of its antagonist long pentraxin\u20103 (PTX<\/jats:styled-content>3) for 6\u00a0days. Real\u2010time PCR<\/jats:styled-content> and alkaline phosphatase (ALP<\/jats:styled-content>) activity were performed to examine the effects exerted by FGF<\/jats:styled-content>\u20102 and PTX<\/jats:styled-content>3.<\/jats:p><\/jats:sec>Results<\/jats:title>SC synovium, no matter facing the articular cavity or covering LB<\/jats:styled-content>, was characterized by increased quantity of synoviocytes and blood vessels. FGF\u20102 was expressed in chondrocytes and fibroblast\u2010like cells of LB<\/jats:styled-content>s, and the wall of blood vessels. Expressions of chondrogenic genes (Sox9<\/jats:italic> and Wnt\u20104<\/jats:italic>), osteogenic genes (Foxc2<\/jats:italic>), FGF\u20102,<\/jats:italic> and VEGF\u2010A<\/jats:italic> mRNA<\/jats:styled-content> were significantly higher in SC<\/jats:styled-content> synovium than that of the control group. The stimulation of FGF<\/jats:styled-content>\u20102 on SC<\/jats:styled-content> synoviocytes increased ALP<\/jats:styled-content> activity and expressions of chondrogenic genes (Sox9<\/jats:italic>, Col2<\/jats:italic>\u03b11<\/jats:italic>, and Aggrecan<\/jats:italic>), osteogenic genes (Foxc2<\/jats:italic>, osteocalcin<\/jats:italic>, and Col1<\/jats:italic>\u03b11<\/jats:italic>), and VEGF\u2010A<\/jats:italic>, but PTX<\/jats:styled-content>3 inhibited these effects.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>FGF<\/jats:styled-content>\u20102 was responsible for the formation of cartilaginous loose bodies and involved in the pathogenesis of SC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12146","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T12:36:46Z","timestamp":1388061406000},"page":"388-394","source":"Crossref","is-referenced-by-count":18,"title":["Fibroblast growth factor 2 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint"],"prefix":"10.1111","volume":"43","author":[{"given":"Yingjie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengxing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School & Hospital of Stomatology Wuhan University Wuhan 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