{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T01:55:04Z","timestamp":1782698104474,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Cancer chemoprevention is defined as the use of chemicals or dietary components to block, inhibit, or reverse the development of cancer in normal or pre\u2010neoplastic tissue. Mentha extract (<jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content>) has antioxidant and antiperoxidant properties. This study was held to investigate the protective and anticancer effect of Mentha leaves aqueous extract on oral epithelium of mice tongues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A total of 80 Egyptian albino mice were divided into three groups. Group I served as control (not subjected to any kind of treatment), and groups <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> were subjected to two\u2010stage chemical carcinogenesis through topical application of dimethylbenz[<jats:italic>a<\/jats:italic>]anthracene (<jats:styled-content style=\"fixed-case\">DMBA<\/jats:styled-content>) followed by formaldehyde on dorsal and ventral surfaces of tongues for 9\u00a0weeks. Mentha leaves extract was administrated to group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> at the same time of cancer induction. Histological changes were assessed in H&amp;E sections at 3\u2010week intervals. The anticarcinogenic effect of Mentha piperita was tested using immunostain with anticaspase antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The oral administration of <jats:styled-content style=\"fixed-case\">ME<\/jats:styled-content> reduced the appearance of dysplastic cellular changes with 61% and inhibited tumor incidence with 100%. Group I showed moderate\u2010to\u2010strong cytoplasmic caspase expression. At 6\u2010week interval, group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> showed weak\u2010to\u2010moderate caspase expression, while sections from group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> showed moderate\u2010to\u2010strong caspase expression. High significant statistical difference in the total score of caspase 3 expression was found between specimens obtained from animals sacrificed at 6\u00a0weeks in groups I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0= 0.001**).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that Mentha piperita has inhibited the initiation and promotion of oral dysplastic lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12150","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T11:59:18Z","timestamp":1390478358000},"page":"484-491","source":"Crossref","is-referenced-by-count":11,"title":["Chemopreventive effect of Mentha piperita on dimethylbenz[<i>a<\/i>]anthracene and formaldehyde\u2010induced tongue carcinogenesis in mice (histological and immunohistochemical study)"],"prefix":"10.1111","volume":"43","author":[{"given":"Rehab F.","family":"Kasem","sequence":"first","affiliation":[{"name":"Faculty of Oral &amp; Dental Medicine Department of Oral Pathology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwa H.","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Faculty of Oral &amp; Dental Medicine Department of Oral Biology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A. 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