{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T16:04:43Z","timestamp":1788624283453,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze whether oxidative stress (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) changes are present in patients with bisphosphonate\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>) <jats:italic>versus<\/jats:italic> controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Oxidative stress was analyzed in serum and unstimulated saliva of three groups: Group 1 consisted of 24 patients who had been treated with intravenous bisphosphonates (iv<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>s) and developed <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, group 2 consisted of 20 patients who had received iv<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>s and did not develop <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, and group 3 comprised 17 control subjects. Reduced glutathione (<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>), malondialdehyde (<jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>), oxidized glutathione (<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>), and 8\u2013oxo\u20107,8\u2010dihydro\u20102\u2010deoxyguanosine (8\u2010oxo\u2010d<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>) levels, as well as the <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> ratio, were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean serum and saliva levels of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GSSG<\/jats:styled-content>, and 8\u2010oxo\u2010d<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> ratio were significantly higher in patients with <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> than in controls. We found no significant difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> according to <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> stage, sex, or location in the jaws. Logistic regression analysis revealed that the <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> ratio was a significant factor predicting the development of <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oxidative stress was detected in patients with <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>, and the <jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content> ratio was the most significant <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> variable found; it was a significant factor predicting the development of <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12151","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T11:59:03Z","timestamp":1390478343000},"page":"371-377","source":"Crossref","is-referenced-by-count":49,"title":["Oxidative stress in bisphosphonate\u2010related osteonecrosis of the jaws"],"prefix":"10.1111","volume":"43","author":[{"given":"Jose","family":"Bagan","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Valencia University Valencia Spain"},{"name":"Service of Stomatology and Maxillofacial Surgery University General Hospital Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo T.","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CIBERobn Servicio de an\u00e1lisis cl\u00cdnicos\u2010CDBI HGUV School of Medicine University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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