{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:35:55Z","timestamp":1770438955771,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Background<\/jats:title>The aim of this study was to identify the expression of MCM<\/jats:styled-content>3, K<\/jats:styled-content>i\u201067 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC<\/jats:styled-content>) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions.<\/jats:p><\/jats:sec>Methods<\/jats:title>The samples were collected from 37 patients with oral leucoplakia (13 with mild dysplasia \u2013 MLD<\/jats:styled-content>, 12 with moderate dysplasia \u2013 MD<\/jats:styled-content> and 12 with severe dysplasia \u2013 SD<\/jats:styled-content>). Eleven samples of mouth floor mucocele (M<\/jats:styled-content>) and 50 floor mouth and tongue samples OSCC<\/jats:styled-content> of untreated patients were included in this study. Immunohistochemical expression of MCM<\/jats:styled-content>3, K<\/jats:styled-content>i\u201067 and p27 of all the groups was analysed. K<\/jats:styled-content>ruskal\u2013W<\/jats:styled-content>allis and D<\/jats:styled-content>unn's test were used to determine differences among groups, and a P<\/jats:styled-content>earson's correlation test was used to evaluate the correlation between the proteins.<\/jats:p><\/jats:sec>Results<\/jats:title>K<\/jats:styled-content>i\u201067 expression was higher in OSCC<\/jats:styled-content> than M<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001) and MLD<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01) groups, and there was a lower expression in M<\/jats:styled-content> compared with MD<\/jats:styled-content> and SD<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.05). Regarding p27, its expression was lower in OSCC<\/jats:styled-content> compared with M<\/jats:styled-content>, MD<\/jats:styled-content> and SD<\/jats:styled-content>. MCM<\/jats:styled-content>3 expression was lower in M<\/jats:styled-content> compared with SD<\/jats:styled-content> and OSCC<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001), and MLD<\/jats:styled-content> showed a lower expression when compared SD<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.01) and OSCC<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001). Moreover, a better correlation was observed between the proteins MCM<\/jats:styled-content>3 and p27 than between K<\/jats:styled-content>i\u201067 and p27 proteins when all lesions were examined together.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study showed that MCM<\/jats:styled-content>3 could be a better marker than K<\/jats:styled-content>i\u201067 for evaluation of dysplastic oral lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12153","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T14:29:16Z","timestamp":1390487356000},"page":"427-434","source":"Crossref","is-referenced-by-count":20,"title":["MCM<\/scp>3 could be a better marker than K<\/scp>i\u201067 for evaluation of dysplastic oral lesions: an immunohistochemical study"],"prefix":"10.1111","volume":"43","author":[{"given":"Aladim Gomes","family":"Lameira","sequence":"first","affiliation":[{"name":"Jo\u00e3o de Barros Barreto University Hospital Bel\u00e9m 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