{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:41:34Z","timestamp":1787060494970,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81072203"],"award-info":[{"award-number":["81072203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272963"],"award-info":[{"award-number":["81272963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30973329"],"award-info":[{"award-number":["30973329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272964"],"award-info":[{"award-number":["81272964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Background<\/jats:title>\n \n Recently, studies indicated that cancer stem cell plays a key role in cancer development and progression. However, the role of cancer stem cell has not been well elucidated in tongue squamous cell carcinoma (\n TSCC<\/jats:styled-content>\n ). The objective of this study was to investigate the relationships between the expressions of stem cell markers and the prognosis of\n TSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Immunohistochemistry was employed to analyse the protein expression levels of\n ALDH<\/jats:styled-content>\n 1,\n CD<\/jats:styled-content>\n 44,\n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 in 66\n TSCC<\/jats:styled-content>\n tissue samples. The results were then evaluated semiquantitatively and compared with other clinicopathological variables.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Immunohistochemistry revealed that the\n ALDH<\/jats:styled-content>\n 1,\n CD<\/jats:styled-content>\n 44,\n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 proteins were overexpressed in the 66\n TSCC<\/jats:styled-content>\n specimens used in this study. Spearman's correlation analysis showed that the expressions of\n ALDH<\/jats:styled-content>\n 1 and\n CD<\/jats:styled-content>\n 44 were significantly correlated with\n SOX<\/jats:styled-content>\n 2 except other proteins (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) and that\n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 were significantly related (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.01). Kaplan\u2013Meier analysis revealed that T category, node metastasis,\n TNM<\/jats:styled-content>\n stage, differentiation and distant metastasis were associated with poor patient survival (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05). Multivariate Cox regression analysis demonstrated that\n SOX<\/jats:styled-content>\n 2, recurrence and distant metastasis were independent prognostic factors of overall survival in patients with\n TSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Taken together, these data suggest that the stem cell markers\n ALDH<\/jats:styled-content>\n 1,\n CD<\/jats:styled-content>\n 44,\n OCT<\/jats:styled-content>\n 4 and\n SOX<\/jats:styled-content>\n 2 are closely related in\n TSCC<\/jats:styled-content>\n , and the expression of\n SOX<\/jats:styled-content>\n 2 can be used as a prognostic indicator of\n TSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12159","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T06:56:04Z","timestamp":1390460164000},"page":"492-498","source":"Crossref","is-referenced-by-count":83,"title":["Correlation of\n ALDH<\/scp>\n 1,\n CD<\/scp>\n 44,\n OCT<\/scp>\n 4 and\n SOX<\/scp>\n 2 in tongue squamous cell carcinoma and their association with disease progression and prognosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Cong\u2010Fa","family":"Huang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral and Maxillofacial Surgery School of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Fu","family":"Wu","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"},{"name":"Department of Oral and Maxillofacial Surgery School of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery School of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707975"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038047"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2319"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12073"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2826"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81769-9"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.07.025"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.9.4.10666"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.33"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2010.01400.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13067663"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp232"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1744"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.020"},{"key":"e_1_2_5_16_1","volume-title":"International Union Against Cancer (UICC): TNM classification of malignant tumors","author":"Sobin LH","year":"2002"},{"key":"e_1_2_5_17_1","first-page":"168","volume-title":"World Health Organization classification of tumours. 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