{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:04:08Z","timestamp":1762542248843,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30973361","81170981","81230022","81200808"],"award-info":[{"award-number":["30973361","81170981","81230022","81200808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Hightech R&D Program of China","award":["2012AA020101"],"award-info":[{"award-number":["2012AA020101"]}]},{"name":"Ph.D. Programs Foundation of Ministry of Education of China","award":["20113234110003"],"award-info":[{"award-number":["20113234110003"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["20100481164"],"award-info":[{"award-number":["20100481164"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"China Postdoctoral Science Foundation Special Funded Project","award":["201104537"],"award-info":[{"award-number":["201104537"]}]},{"DOI":"10.13039\/501100010242","name":"Jiangsu Planned Projects for Postdoctoral Research Funds","doi-asserted-by":"crossref","award":["1101026C"],"award-info":[{"award-number":["1101026C"]}],"id":[{"id":"10.13039\/501100010242","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Background<\/jats:title>The axis inhibition protein 2 (AXIN<\/jats:styled-content>2) is an important regulator of \u03b2\u2010catenin degradation in the W<\/jats:styled-content>nt pathway, which plays a key role in craniofacial morphogenesis. The goal of this study was to investigate the potential relationship between AXIN<\/jats:styled-content>2<\/jats:italic> polymorphisms and the risks of non\u2010syndromic orofacial clefts (NSOC<\/jats:styled-content>) in a C<\/jats:styled-content>hinese H<\/jats:styled-content>an population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Four polymorphisms of AXIN<\/jats:styled-content>2<\/jats:italic> (rs2240307, rs11867417, rs2240308, and rs7591) were selected to perform a case\u2013control study with 599 NSOC<\/jats:styled-content> cases and 602 healthy individuals from a C<\/jats:styled-content>hinese H<\/jats:styled-content>an population. The single nucleotide polymorphisms (SNP<\/jats:styled-content>s) were genotyped on basis of double ligation and multiplex fluorescence PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Weak associations were found between these four SNP<\/jats:styled-content>s and the risk of NSOC<\/jats:styled-content>. Further stratified analysis showed that the overall genotype frequencies of rs2240307 were different between the cleft palate only (CPO<\/jats:styled-content>) group and the control group (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.048), and GG<\/jats:styled-content> genotype markedly contributed to the susceptibility to CPO<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a03.22, 95% CI<\/jats:styled-content>\u00a0=\u00a01.13\u20139.18). The similar effect was also observed on GA<\/jats:styled-content>\/AA<\/jats:styled-content> genotype compared with GG<\/jats:styled-content> homozygote (OR<\/jats:styled-content>\u00a0=\u00a00.30, 95% CI<\/jats:styled-content>\u00a0=\u00a00.11\u20130.84). The results of LD<\/jats:styled-content> analysis between each pair of SNP<\/jats:styled-content>s revealed that two SNP<\/jats:styled-content>s (rs11867417 and rs7591) were in a LD<\/jats:styled-content> block (r<\/jats:italic>2<\/jats:sup>\u00a0>\u00a00.8). But no statistically significant was found between cases and controls from haplotype analysis in these two loci.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The borderline results gave us a hint that rs2240307 contributed to the susceptibility to CPO<\/jats:styled-content> in a C<\/jats:styled-content>hinese H<\/jats:styled-content>an population, which was conductive to improving our awareness of the causes of NSOC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12162","type":"journal-article","created":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T06:48:58Z","timestamp":1391237338000},"page":"554-560","source":"Crossref","is-referenced-by-count":14,"title":["The axis inhibition protein 2 polymorphisms and non\u2010syndromic orofacial clefts susceptibility in a C<\/scp>hinese H<\/scp>an population"],"prefix":"10.1111","volume":"43","author":[{"given":"Yue","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of environment disease prevention and control Jiangsu Provincial Center for Disease Control and Prevention Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchu","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Stomatology Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.1016\/S0140-6736(09)60695-4"},{"doi-asserted-by":"publisher","key":"e_1_2_5_3_1","DOI":"10.1093\/hmg\/ddh052"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.1002\/bdra.20607"},{"doi-asserted-by":"publisher","key":"e_1_2_5_5_1","DOI":"10.1093\/ejo\/26.1.7"},{"doi-asserted-by":"publisher","key":"e_1_2_5_6_1","DOI":"10.1016\/j.molmed.2011.07.007"},{"doi-asserted-by":"publisher","key":"e_1_2_5_7_1","DOI":"10.1038\/ng.242"},{"doi-asserted-by":"publisher","key":"e_1_2_5_8_1","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_2_5_9_1","first-page":"37","article-title":"Cleft lip and palate: review","volume":"35","author":"Ciminello FS","year":"2009","journal-title":"Compr Ther"},{"doi-asserted-by":"publisher","key":"e_1_2_5_10_1","DOI":"10.1002\/bdra.20430"},{"doi-asserted-by":"publisher","key":"e_1_2_5_11_1","DOI":"10.1086\/510518"},{"doi-asserted-by":"publisher","key":"e_1_2_5_12_1","DOI":"10.4103\/0970-0358.57182"},{"doi-asserted-by":"publisher","key":"e_1_2_5_13_1","DOI":"10.1111\/odi.12033"},{"doi-asserted-by":"publisher","key":"e_1_2_5_14_1","DOI":"10.1002\/ajmg.a.33624"},{"doi-asserted-by":"publisher","key":"e_1_2_5_15_1","DOI":"10.1089\/dna.2010.1185"},{"doi-asserted-by":"publisher","key":"e_1_2_5_16_1","DOI":"10.1242\/dev.01676"},{"doi-asserted-by":"publisher","key":"e_1_2_5_17_1","DOI":"10.1111\/j.1600-0722.2011.00938.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_18_1","DOI":"10.1597\/11-132"},{"doi-asserted-by":"publisher","key":"e_1_2_5_19_1","DOI":"10.1159\/000337619"},{"doi-asserted-by":"publisher","key":"e_1_2_5_20_1","DOI":"10.1159\/000056942"},{"key":"e_1_2_5_21_1","first-page":"1029","article-title":"Strong association between lung cancer and the AXIN2 polymorphism","volume":"2","author":"Gunes EG","year":"2009","journal-title":"Mol Med Rep"},{"doi-asserted-by":"publisher","key":"e_1_2_5_22_1","DOI":"10.1007\/s12032-010-9588-y"},{"doi-asserted-by":"publisher","key":"e_1_2_5_23_1","DOI":"10.1086\/386293"},{"doi-asserted-by":"publisher","key":"e_1_2_5_24_1","DOI":"10.1002\/bdra.20489"},{"doi-asserted-by":"publisher","key":"e_1_2_5_25_1","DOI":"10.14219\/jada.archive.2009.0022"},{"doi-asserted-by":"publisher","key":"e_1_2_5_26_1","DOI":"10.1111\/j.1601-0825.2010.01741.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_27_1","DOI":"10.1111\/j.1538-7836.2012.04815.x"},{"doi-asserted-by":"publisher","key":"e_1_2_5_28_1","DOI":"10.1038\/sj.cr.7290272"},{"doi-asserted-by":"publisher","key":"e_1_2_5_29_1","DOI":"10.1016\/j.jpeds.2009.06.020"},{"doi-asserted-by":"publisher","key":"e_1_2_5_30_1","DOI":"10.1177\/154405910708601013"},{"doi-asserted-by":"publisher","key":"e_1_2_5_31_1","DOI":"10.1007\/s10038-005-0353-6"},{"doi-asserted-by":"publisher","key":"e_1_2_5_32_1","DOI":"10.1002\/ajmg.a.35359"},{"doi-asserted-by":"publisher","key":"e_1_2_5_33_1","DOI":"10.1177\/0022034512440578"},{"doi-asserted-by":"publisher","key":"e_1_2_5_34_1","DOI":"10.1002\/bdra.23056"},{"doi-asserted-by":"publisher","key":"e_1_2_5_35_1","DOI":"10.1016\/j.archoralbio.2007.04.005"},{"doi-asserted-by":"publisher","key":"e_1_2_5_36_1","DOI":"10.1016\/j.devcel.2009.06.016"},{"doi-asserted-by":"publisher","key":"e_1_2_5_37_1","DOI":"10.1128\/MCB.22.4.1172-1183.2002"},{"doi-asserted-by":"publisher","key":"e_1_2_5_38_1","DOI":"10.1242\/dev.01786"},{"doi-asserted-by":"publisher","key":"e_1_2_5_39_1","DOI":"10.1016\/j.mod.2006.10.002"},{"doi-asserted-by":"publisher","key":"e_1_2_5_40_1","DOI":"10.1177\/0022034511401622"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12162","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:35:36Z","timestamp":1695573336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jop.12162"],"URL":"https:\/\/doi.org\/10.1111\/jop.12162","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"type":"print","value":"0904-2512"},{"type":"electronic","value":"1600-0714"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}