{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:41Z","timestamp":1788872381763,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical University of Bia\u0142ystok Grants","award":["133-70873L"],"award-info":[{"award-number":["133-70873L"]}]},{"name":"Medical University of Bia\u0142ystok Grants","award":["133-70874L"],"award-info":[{"award-number":["133-70874L"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>However, there are some informations on the salivary glands involvement in systemic sclerosis, and there is a lack of any data about salivary glands function depending on systemic sclerosis subsets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The unstimulated and stimulated salivary flow, the activity of peroxidase, the total amount of lactoferrin, lysozyme and s\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      g\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      were determined in two subgroups of systemic sclerosis and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the unstimulated saliva of both patients groups, the salivary flow, the output of total protein and peroxidase activity were significantly lower; the total: s\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      g\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      and lactoferrin were significantly higher as compared with the control. In the stimulated saliva of the patients with limited form, the total lysozyme and peroxidase activity were significantly higher than in the control. In the stimulated saliva of the patients with diffused form, the salivary flow was significantly lower and the total s\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      g\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      and peroxidase activity were significantly higher than in the control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic sclerosis regardless of its subset affects salivary defense system of human unstimulated and stimulated saliva. Patients with the limited form experience the same impairment of the submandibular glands function as compared with patients with the diffused form. Only patients with the diffused form are deficient in respect of stimulated saliva secretion; the parotid glands of the patients with the limited form have a good secretory capacity in comparison with the healthy control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12166","type":"journal-article","created":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T07:47:15Z","timestamp":1392191235000},"page":"521-529","source":"Crossref","is-referenced-by-count":18,"title":["Salivary: flow and proteins of the innate and adaptive immunity in the limited and diffused systemic sclerosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ma\u0142gorzata","family":"Kna\u015b","sequence":"first","affiliation":[{"name":"The Institute of Health Care The Higher Vocational School\u2010Prof. E.F. Szczepanik Suwalki Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zalewska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napoleon","family":"Waszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julita","family":"Szulimowska","sequence":"additional","affiliation":[{"name":"Department of Paedodontics Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Dzi\u0119cio\u0142","sequence":"additional","affiliation":[{"name":"Department of the Human Anatomy Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Sierakowski","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Internal Diseases Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Waszkiel","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Medical University in Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.067"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05127.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.12.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012595961-2\/50066-4"},{"key":"e_1_2_6_6_1","first-page":"203","article-title":"Sj\u00f6gren's syndrome in rheumatoid arthritis and progressive systemic sclerosis. 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