{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:21:16Z","timestamp":1788870076988,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Graduate Innovation Foundation of Fudan University","award":["EZF152302"],"award-info":[{"award-number":["EZF152302"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\n Background<\/jats:title>\n \n Emerging evidence indicates that the interaction between glucocorticoid receptor \u03b1 (\n GR<\/jats:styled-content>\n \u03b1) and nuclear factor \u03baB (\n NF<\/jats:styled-content>\n \u2010\u03baB) is a key pathogenetic cross talk in the autoimmune and inflammatory disorders. The objective of this study was to determine the\n GR<\/jats:styled-content>\n \u03b1 expression in patients with oral lichen planus (\n OLP<\/jats:styled-content>\n ) and investigate its correlation with\n NF<\/jats:styled-content>\n \u2010\u03baB in\n OLP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We compared the expression of\n GR<\/jats:styled-content>\n \u03b1 and\n NF<\/jats:styled-content>\n \u2010\u03baB in oral biopsy specimens from patients with\n OLP<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u00a0=\u00a032) against normal controls (\n n<\/jats:italic>\n \u00a0=\u00a012) and investigated the correlation between the expression of\n GR<\/jats:styled-content>\n \u03b1 and\n NF<\/jats:styled-content>\n \u2010\u03baB in\n OLP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Immunohistochemistry showed that GR\u03b1 mainly expressed in the cytoplasm of keratinocytes of basal and spinosum layer of\n OLP<\/jats:styled-content>\n . Both real\u2010time quantitative PCR and Western blots revealed that the\n mRNA<\/jats:styled-content>\n and protein expression levels of GR\u03b1 were decreased compared with normal controls (both\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). Conversely, those levels of nuclear factor\u2010kappa B (NF\u2010\u03baB) were increased compared with normal controls (both\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). Importantly, a significant inverse correlation between the GR\u03b1 and NF\u2010\u03baB was found (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our findings demonstrated that low expression of\n GR<\/jats:styled-content>\n \u03b1 in\n OLP<\/jats:styled-content>\n correlates with activation of\n NF<\/jats:styled-content>\n \u2010\u03baB, which indicates that the cross talk between\n GR<\/jats:styled-content>\n \u03b1 and\n NF<\/jats:styled-content>\n \u2010\u03baB in\n OLP<\/jats:styled-content>\n may become a new therapeutic target and represent a new approach to explore the pathogenesis of\n OLP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12168","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T19:42:18Z","timestamp":1392925338000},"page":"600-605","source":"Crossref","is-referenced-by-count":9,"title":["Low expression of glucocorticoid receptor \u03b1 in oral lichen planus correlates with activation of nuclear factor \u03ba\n B<\/scp>\n : a preliminary study"],"prefix":"10.1111","volume":"43","author":[{"given":"Xue\u2010cai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010xiang","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia\u2010xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Huashan Hospital Fudan University Shanghai 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