{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:32:24Z","timestamp":1789025544815,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81102049"],"award-info":[{"award-number":["81102049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"crossref","award":["11ZR1420600"],"award-info":[{"award-number":["11ZR1420600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012150","name":"Shanghai Leading Academic Discipline Project","doi-asserted-by":"crossref","award":["S30206"],"award-info":[{"award-number":["S30206"]}],"id":[{"id":"10.13039\/501100012150","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,9]]},"abstract":"\n Purpose<\/jats:title>\n \n High\u2010grade mucoepidermoid carcinoma (\n MEC<\/jats:styled-content>\n ) is an infrequent malignant neoplasm originates most commonly in the salivary glands with poor prognosis. Thus far, there is little knowledge on\n MUC<\/jats:styled-content>\n \u20101 expression in high\u2010grade\n MEC<\/jats:styled-content>\n or how it may relate to patient survival. The aim of this study was to determine the extent of\n MUC<\/jats:styled-content>\n \u20101 expression in high\u2010grade\n MEC<\/jats:styled-content>\n and correlate expression with clinic outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Surgical specimens from 62 cases of primary high\u2010grade\n MEC<\/jats:styled-content>\n and 10 cases of normal salivary gland tissue were examined by immunohistochemistry. The relationship between\n MUC<\/jats:styled-content>\n \u20101 expression and the clinicopathological data and patient survival was analyzed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The disease\u2010free survival rates were 54.6% (3\u00a0years) and 37.7% (5\u00a0years) for high\u2010grade\n MEC<\/jats:styled-content>\n patients. Patient who with primary location at submandibular gland have the worst prognosis (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.042) in comparing with other sites. High expression of\n MUC<\/jats:styled-content>\n \u20101 in high\u2010grade\n MEC<\/jats:styled-content>\n was significantly correlated with lymphatic\/regional metastasis (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.003) and clinic stage (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.02), and high expression of\n MUC<\/jats:styled-content>\n \u20101 (>75%) was confirmed to be significant independent prognostic factors in high\u2010grade\n MEC<\/jats:styled-content>\n patients [\n HR<\/jats:styled-content>\n 2.929 (95%\n CI<\/jats:styled-content>\n 1.246\u20136.881);\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.0137].\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The findings suggest that high levels of\n MUC<\/jats:styled-content>\n \u20101 expression may be a potential marker for worse outcome in high\u2010grade\n MEC<\/jats:styled-content>\n and could be used as a new molecule target to improve outcomes for these patients in the future.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12170","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T05:17:17Z","timestamp":1392614237000},"page":"579-584","source":"Crossref","is-referenced-by-count":15,"title":["Increased expression of\n MUC<\/scp>\n \u20101 has close relation with patient survivor in high\u2010grade salivary gland mucoepidermoid carcinoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Li","family":"Siyi","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial\u2010Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Shengwen","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial\u2010Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruan","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial\u2010Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wenjun","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial\u2010Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Lizheng","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Chenping","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial\u2010Head & Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomotology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"99","volume-title":"Disease of the salivary glands","author":"Cornog JL","year":"1976"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.11.1763"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000213058.74509.d3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930460207"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.2.174"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2872-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26697"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011379725811"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1251"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2006.01.002"},{"key":"e_1_2_5_12_1","first-page":"221","volume-title":"World health organization classification of tumors. 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