{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:32:19Z","timestamp":1726759939305},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Council for Scientific and Technological Development (CNPq)\/Brazil"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)\/Brazil"},{"name":"MS\/SCTIE\/Decit, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral candidiasis is an important side effect of topical corticotherapy. The purpose of this study was to assess oral mucosa colonization by five <jats:italic>Candida<\/jats:italic> species during topical corticotherapy and to investigate <jats:italic>Candida<\/jats:italic> spp. pathogenicity and <jats:italic>in vitro<\/jats:italic> susceptibility to fluconazole and amphotericin B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oral swabbing samples from 11 erosive oral lichen planus (OLP) patients were collected before (day 0) and at days 7 and 30 of topical corticotherapy. Conventional methods for identification and quantification of <jats:italic>Candida<\/jats:italic> species, quantitative PCR (qPCR), pathogenicity tests and <jats:italic>in vitro<\/jats:italic> susceptibility to fluconazole and amphotericin B assays were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Candida albicans<\/jats:italic> was the most prevalent species in the oral mucosa after corticotherapy. Increased number of colony\u2010forming units (CFU) and <jats:italic>Candida albicans<\/jats:italic> DNA copies were observed at day 30 of corticotherapy, despite no clinical evidence of candidiasis in any patient. Colony\u2010forming units' count of <jats:italic>Candida<\/jats:italic> species was less sensitive than qPCR, but both methods positively correlated. No resistance to fluconazole or amphotericin B was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical corticoid used for oral erosive lichen planus treatment was associated with increase in <jats:italic>Candida<\/jats:italic> spp., in particular, <jats:italic>C.\u00a0albicans<\/jats:italic>, in the oral cavity, independent of clinical manifestation of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12174","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:43:29Z","timestamp":1392943409000},"page":"570-575","source":"Crossref","is-referenced-by-count":10,"title":["Kinetics of oral colonization by <i>Candida<\/i> spp. during topical corticotherapy for oral lichen planus"],"prefix":"10.1111","volume":"43","author":[{"given":"Thais dos Santos Fontes","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas 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