{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:28:18Z","timestamp":1790029698134,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,14]],"date-time":"2014-06-14T00:00:00Z","timestamp":1402704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100766"],"award-info":[{"award-number":["81100766"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Commission of Shanghai","award":["08DZ2271100"],"award-info":[{"award-number":["08DZ2271100"]}]},{"DOI":"10.13039\/501100012150","name":"Shanghai Leading Academic Discipline Project","doi-asserted-by":"crossref","award":["S30206"],"award-info":[{"award-number":["S30206"]}],"id":[{"id":"10.13039\/501100012150","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Innovative Research Team of the Shanghai Municipal Education Commission"},{"name":"Shanghai Jiaotong University of Medicine Foundation","award":["YZ1024"],"award-info":[{"award-number":["YZ1024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background<\/jats:title>\n \n An increasing number of studies have revealed that micro\n RNA<\/jats:styled-content>\n (mi\n RNA<\/jats:styled-content>\n ) contributes to the pathogenesis of autoimmune diseases. The objective of this study is to investigate the miR\u2010146a and miR\u2010155 levels in peripheral mononuclear blood cells from patients with primary Sj\u00f6gren's syndrome (\n pSS<\/jats:styled-content>\n ) who were not receiving medications and to examine the correlations between these mi\n RNA<\/jats:styled-content>\n levels and the clinical features of the disease.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Using real\u2010time polymerase chain reaction analysis of mi\n RNA<\/jats:styled-content>\n s, the miR\u2010146a and miR\u2010155 expression levels were assessed in peripheral mononuclear blood cells from 27 patients with\n pSS<\/jats:styled-content>\n and 22 healthy controls, and the relationships between these mi\n RNA<\/jats:styled-content>\n levels and the visual analog scale (\n VAS<\/jats:styled-content>\n ) scores for dry mouth, dry eyes, and parotid gland swelling were investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with the healthy controls, the miR\u2010146a expression level was significantly increased in the patients with\n pSS<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.0182) and was positively correlated with the VAS scores for parotid swelling (\n r<\/jats:italic>\n \u00a0=\u00a00.4475,\n P<\/jats:italic>\n \u00a0=\u00a00.0192) and dry eyes (\n r<\/jats:italic>\n \u00a0=\u00a00.4051,\n P<\/jats:italic>\n \u00a0=\u00a00.0361). Although the miR\u2010155 expression level was significantly decreased in the patients with\n pSS<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.0131), the miR\u2010155 expression positively correlated with the VAS score for dry eyes (\n r<\/jats:italic>\n \u00a0=\u00a00.4894,\n P<\/jats:italic>\n \u00a0=\u00a00.0096).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our results demonstrated miR\u2010146a overexpression and miR\u2010155 underexpression in the peripheral mononuclear blood cells of the patients with\n pSS<\/jats:styled-content>\n . Furthermore, the expression levels of these miRNAs correlated with the patients' clinical features. Our data suggest that miR\u2010146a and miR\u2010155 might play important roles in the pathogenesis of\n pSS<\/jats:styled-content>\n and that their expression levels may be useful for diagnosing\n pSS<\/jats:styled-content>\n and for predicting disease activity and therapeutic responses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12187","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T14:22:58Z","timestamp":1402928578000},"page":"792-797","source":"Crossref","is-referenced-by-count":86,"title":["miR\u2010146a and miR\u2010155 expression in\n PBMC<\/scp>\n s from patients with Sj\u00f6gren's syndrome"],"prefix":"10.1111","volume":"43","author":[{"given":"Huan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Oral Surgery Affiliated Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Affiliated Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Affiliated Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"},{"name":"Department of Oral and Maxillofacial\u2010Head and Neck Oncology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang\u2010qi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Affiliated Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,14]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"791","article-title":"Management of patients presenting with Sjogren's syndrome. 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