{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:38:00Z","timestamp":1778787480335,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,14]],"date-time":"2014-06-14T00:00:00Z","timestamp":1402704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81060085"],"award-info":[{"award-number":["81060085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81260167"],"award-info":[{"award-number":["81260167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Background<\/jats:title>Highly active antiretroviral therapy (HAART<\/jats:styled-content>) as an effective therapy for immune reconstruction among patients with HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> might have influence on oral C<\/jats:styled-content>andida<\/jats:italic> status. We investigated oral C<\/jats:styled-content>andida<\/jats:italic> carriage, distribution, and antifungal susceptibility dynamically during the first year of HAART<\/jats:styled-content> among adult HIV<\/jats:styled-content>\u2010infected patients in Guangxi, China.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010five adult HIV<\/jats:styled-content>\u2010infected patients who received their first year HAART<\/jats:styled-content> in the AIDS<\/jats:styled-content> clinic of the Guangxi Center for Disease Control (CDC<\/jats:styled-content>) and 31 healthy individuals were recruited. Clinical information and oral examinations were obtained. Oral rinses taken from patients at baseline, 3, 6, 12\u00a0months during HAART<\/jats:styled-content>, respectively, were cultured, and Candida<\/jats:italic> species were identified following standard microbiological techniques. In vitro antifungal susceptibilities were tested by the broth microdilution method.<\/jats:p><\/jats:sec>Results<\/jats:title>The oral C<\/jats:styled-content>andida<\/jats:italic> load decreased gradually in the 45 patients with HIV<\/jats:styled-content>\/AIDS<\/jats:styled-content> during the first year of HAART<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.050). Among 176 C<\/jats:styled-content>andida<\/jats:italic> isolates, C<\/jats:styled-content>andida albicans<\/jats:italic> (114\/176) was the predominant species, and C<\/jats:styled-content>andida parapsilosis<\/jats:italic> (23\/62) was the most common non\u2010albicans<\/jats:italic> species. We found the frequency of resistance to fluconazole and itraconazole of Candida<\/jats:italic> isolated from our samples increased (P<\/jats:italic>\u00a0<\u00a00.05) after 12\u00a0months of HAART<\/jats:styled-content>. In addition, the frequency of C<\/jats:styled-content>.\u00a0albicans<\/jats:italic> isolates resistant to fluconazole and itraconazole was on the rise (P<\/jats:italic>\u00a0<\u00a00.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The Candida<\/jats:italic> load decreased with increased CD<\/jats:styled-content>4+<\/jats:sup> T cell counts, and C<\/jats:styled-content>.\u00a0albicans<\/jats:italic> was still the prevailing species. Further, a trend toward more frequent in vitro resistance to fluconazole and itraconazole was observed. Our results provide reference for treatment and prevention of oral candidiasis among this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12192","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T18:23:19Z","timestamp":1402942999000},"page":"696-703","source":"Crossref","is-referenced-by-count":15,"title":["Dynamic analysis of oral C<\/scp>andida<\/i> carriage, distribution, and antifungal susceptibility in HIV<\/scp>\u2010infected patients during the first year of highly active antiretroviral therapy in G<\/scp>uangxi, C<\/scp>hina"],"prefix":"10.1111","volume":"43","author":[{"given":"Lanlan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine College of Stomatology Guangxi Medical University Guangxi China"},{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment Guangxi Medical University Guangxi 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