{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:40Z","timestamp":1788870340129,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,14]],"date-time":"2014-06-14T00:00:00Z","timestamp":1402704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shandong medical and health science and technology","award":["2013WS0234"],"award-info":[{"award-number":["2013WS0234"]}]},{"name":"Traditional Chinese medicine of Shandong province science and technology research","award":["2013-158"],"award-info":[{"award-number":["2013-158"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,11]]},"abstract":"\n Background<\/jats:title>\n \n Oral lichen planus (\n OLP<\/jats:styled-content>\n ) is a chronic inflammatory disease of oral mucosa in which the\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cell\u2010mediated cytotoxicity is regarded as a major mechanism of pathogenesis. The main objective of this study is to investigate\n in situ<\/jats:italic>\n expression and secretion of thymic stromal lymphopoietin (\n TSLP<\/jats:styled-content>\n ) in specimens and sera from patients with oral lichen planus.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty\u2010six patients with\n OLP<\/jats:styled-content>\n and 35 donors enrolled in specimen and serum collection. Immunohistochemical method and immunofluorescence double\u2010staining method were used to detect the expression of thymic stromal lymphopoietin and its receptor (\n TSLPR<\/jats:styled-content>\n ) together with\n CD<\/jats:styled-content>\n 8 in\n OLP<\/jats:styled-content>\n specimens. Enzyme\u2010linked immunosorbent assay (\n ELISA<\/jats:styled-content>\n ) was used to detect\n TSLP<\/jats:styled-content>\n secretion.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n More\n TSLP<\/jats:styled-content>\n \u2010 or\n TSLPR<\/jats:styled-content>\n \u2010positive cells showed in\n OLP<\/jats:styled-content>\n specimens than in normal controls, and\n TSLP<\/jats:styled-content>\n \u2010positive cells were mainly in the epithelium, while\n TSLPR<\/jats:styled-content>\n \u2010positive cells mainly in the lamina propria. Furthermore, the number of\n TSLP<\/jats:styled-content>\n \u2010positive cells in the stratum basal was associated with the amount of mononuclear cells infiltrating in the lamina propria of\n OLP<\/jats:styled-content>\n specimens. Among infiltrating mononuclear cells in the lamina propria, some\n CD<\/jats:styled-content>\n 8\u2010positive cells also expressed\n TSLPR<\/jats:styled-content>\n . The\n TSLP<\/jats:styled-content>\n serum level of patients with\n OLP<\/jats:styled-content>\n was significantly higher than of healthy donors, but there was no statistically difference between two clinical subtypes of\n OLP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our findings provided the first evidence that\n TSLP<\/jats:styled-content>\n may enroll in the pathology of\n OLP<\/jats:styled-content>\n and the\n TSLP<\/jats:styled-content>\n \u2013\n TSLPR<\/jats:styled-content>\n interaction may play an important role in it.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12196","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T14:23:51Z","timestamp":1402928631000},"page":"740-745","source":"Crossref","is-referenced-by-count":5,"title":["In situ<\/i>\n expression and serum level of thymic stromal lymphopoietin in oral lichen planus"],"prefix":"10.1111","volume":"43","author":[{"given":"Mingxia","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Stomatology Qilu Hospital and Institute of Stomatology Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanye","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Stomatology Qilu Hospital and Institute of Stomatology Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Qilu Hospital and Institute of Stomatology Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Qilu Hospital and Institute of Stomatology Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cadre Health Care Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Science Qilu Hospital of Shandong University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengcai","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Stomatology Qilu Hospital and Institute of Stomatology Shandong University Jinan Shandong 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