{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:54:42Z","timestamp":1767995682557,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polish Commission for Scientific Research","award":["KBN - N 403 00632\/0312"],"award-info":[{"award-number":["KBN - N 403 00632\/0312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Lichen planus<\/jats:italic> together with its oral variant is a chronic, inflammatory disease of the skin and the mucosa of unclear aetiology and with an unpredictable course that still poses a major problem in terms of diagnosis and treatment. The objective of this study was to assess the concentrations of interleukin\u20106 (IL\u20106) and neopterin in saliva and serum of patients with <jats:italic>lichen planus<\/jats:italic> (including reticular and erosive form of oral <jats:italic>lichen planus<\/jats:italic>) and to compare them with the concentrations observed in healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study material comprised serum and saliva samples from 56 patients diagnosed with <jats:italic>lichen planus<\/jats:italic> and 56 healthy volunteers. The ELISA test was used to measure concentrations of IL\u20106 and neopterin in the serum and saliva of the study participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentrations of IL\u20106 in saliva and serum of patients with <jats:italic>lichen planus<\/jats:italic> were significantly higher than in controls (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0002; <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). The difference remains significant after adjustment for gingivitis and age. Patients with atrophic\u2010erosive oral <jats:italic>lichen planus<\/jats:italic> had significantly higher IL\u20106 concentrations in their saliva compared to patients with reticular form of disease (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.01). The concentrations of neopterin were significantly higher in the serum but not in saliva of <jats:italic>lichen planus<\/jats:italic> patients vs. controls (<jats:italic>P<\/jats:italic> &lt;0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum levels of proinflammatory cytokines IL\u20106 and neopterin are increased in lichen planus as well as the salivary concentrations of IL\u20106. The differences observed in IL\u20106 levels in patients with erosive\u2010atrophic forms of oral <jats:italic>lichen planus<\/jats:italic> may indicate a substantial role played by the cytokine in the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12199","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T12:56:44Z","timestamp":1415019404000},"page":"734-739","source":"Crossref","is-referenced-by-count":44,"title":["Interleukin\u20106 and neopterin levels in the serum and saliva of patients with <i><scp>L<\/scp>ichen <scp>P<\/scp>lanus<\/i> and oral <i><scp>L<\/scp>ichen <scp>P<\/scp>lanus<\/i>"],"prefix":"10.1111","volume":"43","author":[{"given":"Ayman","family":"Abdel\u2010Haq","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Medicine Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Kusnierz\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Diagnostics Chair of Clinical Biochemistry Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"Darczuk","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza","family":"Sobuta","sequence":"additional","affiliation":[{"name":"Department of Diagnostics University Hospital Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Dumnicka","sequence":"additional","affiliation":[{"name":"Department of Medical Diagnostics Faculty of Pharmacy Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wojas\u2010Pelc","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Chomyszyn\u2010Gajewska","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine Jagiellonian University Collegium Medicum Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.84474"},{"key":"e_1_2_5_3_1","first-page":"259","article-title":"Oral lichen planus update: clinical characteristics, treatment response and malignant transformation","volume":"10","author":"Silverman S","year":"1997","journal-title":"Am J 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