{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:08:47Z","timestamp":1768770527378,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A clinical investigation of the potential correlation of two single\u2010nucleotide polymorphisms at \u2212137 (G\/C) and \u2212607 (C\/A) in the promoter region of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 gene, with the susceptibility to aphthous stomatitis and Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient and Methods<\/jats:title><jats:p>This study included 80 aphthous stomatitis patients and 80 patients with Beh\u00e7et's disease. Eighty healthy subjects were enrolled as a control group. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 single\u2010nucleotide polymorphisms at \u2212607 and \u2212137 regions were analyzed using polymerase chain reaction\u2013restriction fragment length polymorphism analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype and allele distributions of the two regions did not differ significantly between patients with aphthous stomatitis and controls. The genotype and allele distributions at \u2212607 were significantly different between patients with Beh\u00e7et's disease [<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.044), C allele (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043), A allele (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043)], and controls. The frequency of the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype at position \u2212137 in patients with Beh\u00e7et's disease was associated only with a higher rate of ocular manifestations (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>= 1.4, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>= 0.76\u20132.7, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 gene polymorphisms were not associated with any susceptibility to aphthous stomatitis, while a positive association was found with patients with Beh\u00e7et's disease regarding \u2212607 promoter site. Moreover, patients with Beh\u00e7et's disease carrying the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype at position \u2212137 had a higher risk of developing ocular manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12200","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:42:21Z","timestamp":1402965741000},"page":"746-753","source":"Crossref","is-referenced-by-count":11,"title":["<scp>IL<\/scp>\u201018 gene polymorphisms in aphthous stomatitis vs. Beh\u00e7et's disease in a cohort of Egyptian patients"],"prefix":"10.1111","volume":"43","author":[{"given":"Hala H. A.","family":"Hazzaa","sequence":"first","affiliation":[{"name":"Oral Medicine, Diagnosis, Periodontology and Radiology Faculty of Dental Medicine Al Azhar University (Girls Branch) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weam A. 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