{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:32:55Z","timestamp":1788870775692,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DGKFO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,1]]},"abstract":"\n Background<\/jats:title>\n \n Juvenile idiopathic arthritis (\n JIA<\/jats:styled-content>\n ) of the temporomandibular joint (\n TMJ<\/jats:styled-content>\n ) can cause severe growth disturbances of the craniomandibular system. Antigen\u2010induced arthritis (\n AIA<\/jats:styled-content>\n ) of the rabbit\n TMJ<\/jats:styled-content>\n is simulating the inflammatory process of the\n TMJ<\/jats:styled-content>\n in\n JIA<\/jats:styled-content>\n . The aim of this study was to investigate the effect of a systemic administration of the tumor necrosis factor\u2010alpha (\n TNF<\/jats:styled-content>\n \u2010\u03b1) antagonist etanercept on\n AIA<\/jats:styled-content>\n in rabbits by means of three different histological staining methods.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n After sensitization, a bilateral arthritis of the\n TMJ<\/jats:styled-content>\n was induced and maintained by repeated intra\u2010articular administrations of ovalbumin in 12\n N<\/jats:styled-content>\n ew\n Z<\/jats:styled-content>\n ealand white rabbits aged 10\u00a0weeks. From the 13th week of age, 6 of the 12 rabbits received weekly subcutaneous injections of etanercept, and the other 6 animals remained without therapy. Another 6 animals served as controls, receiving no treatment or intra\u2010articular injections at all. After euthanasia at the age of 22\u00a0weeks, all\n TMJ<\/jats:styled-content>\n s were retrieved en bloc. Sagittal sections were cut and stained with hematoxylin\u2013eosin (\n H<\/jats:styled-content>\n \u2010\n E<\/jats:styled-content>\n ),\n S<\/jats:styled-content>\n afranin\u2010\n O<\/jats:styled-content>\n for the evaluation of the\n M<\/jats:styled-content>\n ankin score, and tartrate\u2010resistant acid phosphatase (\n TRAP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In the arthritis group, a chronic inflammation with degeneration of the articular cartilage was visible. In the etanercept group, the signs of cartilage degeneration were significantly reduced but present. In contrast, the joints in the control group were inconspicuous. A strong correlation between the\n M<\/jats:styled-content>\n ankin score and\n TRAP<\/jats:styled-content>\n \u2010positive cells could be found.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Antigen\u2010induced arthritis causes severe damage in the\n TMJ<\/jats:styled-content>\n of young rabbits. An improvement seems to be achievable by a systemic administration of etanercept.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12201","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T20:42:16Z","timestamp":1402951336000},"page":"67-74","source":"Crossref","is-referenced-by-count":4,"title":["Histomorphometry in antigen\u2010induced arthritis of the rabbit temporomandibular joint"],"prefix":"10.1111","volume":"44","author":[{"given":"S.","family":"Rafayelyan","sequence":"first","affiliation":[{"name":"Department of Orthodontics Dentofacial Orthopedics and Pedodontics Center for Dental and Craniofacial Sciences Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Radlanski","sequence":"additional","affiliation":[{"name":"Department of Oral Structural Biology Center for Dental and Craniofacial Sciences Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Minden","sequence":"additional","affiliation":[{"name":"German Rheumatism Research Centre Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pischon","sequence":"additional","affiliation":[{"name":"Department of Periodontics Center for Dental and Craniofacial Sciences Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u2010G.","family":"Jost\u2010Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Dentofacial Orthopedics and Pedodontics Center for Dental and Craniofacial Sciences Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Pr\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Dentofacial Orthopedics and Pedodontics Center for Dental and Craniofacial Sciences Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.09.011"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem271"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00166-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2004.09.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.053"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.1.94"},{"key":"e_1_2_5_8_1","first-page":"162","article-title":"A 2\u2010year follow\u2010up study of enhanced magnetic resonance imaging and clinical examination of the temporomandibular joint in children with juvenile idiopathic arthritis","volume":"32","author":"K\u00fcseler A","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.830146"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12008"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120437"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjr116"},{"key":"e_1_2_5_13_1","first-page":"2109","article-title":"Resorption of the temporomandibular condylar bone according to subtypes of juvenile chronic arthritis","volume":"28","author":"Pedersen TK","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_5_14_1","first-page":"1406","article-title":"Contrast enhanced magnetic resonance imaging as a method to diagnose early inflammatory changes in the temporomandibular joint in children with juvenile chronic arthritis","volume":"25","author":"K\u00fcseler A","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740601154368"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0011-8532(22)01741-4","article-title":"Craniofacial growth","volume":"44","author":"Ranly DM","year":"2000","journal-title":"Dent Clin North Am"},{"key":"e_1_2_5_17_1","first-page":"1","article-title":"Juvenile chronic arthritis. Dentofacial morphology, growth, mandibular function and orthodontic treatment","volume":"109","author":"Kjellberg H","year":"1995","journal-title":"Swed Dent J Suppl"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/13.6.423"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00008.x"},{"issue":"1","key":"e_1_2_5_20_1","first-page":"140","article-title":"Role of tumour necrosis factor alpha in experimental arthritis: separate activity of interleukin 1beta in chronicity and cartilage destruction","volume":"58","author":"Van den Berg WB","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00367.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/319516a0"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-002-0050-9"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90015-6"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-9-52"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.08.012"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.840580"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.823154"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421103"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21885"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740121001"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00630.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-5"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01056.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00934.x"},{"key":"e_1_2_5_36_1","first-page":"576","article-title":"Condylar lesions in relation to mandibular growth in untreated and intra\u2010articular corticosteroid\u2010treated experimental temporomandibular joint arthritis","volume":"28","author":"Stoustrup P","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_37_1","first-page":"79","article-title":"Methods for cartilage and subchondral bone histomorphometry","volume":"101","author":"Pastoureau P","year":"2004","journal-title":"Methods Mol Med"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjm096"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153030-00009"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00982-1"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.06.008"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.2319\/122810-749.1"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2011.01203.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M502469200"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/518094"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(67)90094-5"},{"key":"e_1_2_5_47_1","first-page":"259","article-title":"Longitudinal roentgen cephalometric study of the growth of the New Zealand white rabbit: cumulative and biweekly incremental growth rates for skull and mandible","volume":"6","author":"Masoud I","year":"1986","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(88)90045-3"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092270204"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90049-E"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345990780080801"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02037.x"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0058"},{"key":"e_1_2_5_54_1","first-page":"441","article-title":"Contrast\u2010enhanced MRI compared to histological findings in the temporomandibular joint of antigen\u2010induced arthritis in young rabbits","volume":"22","author":"K\u00fcseler A","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0085-2"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0904-2512.2001.10057.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(96)80036-9"},{"key":"e_1_2_5_58_1","first-page":"222","volume-title":"Textbook of pediatric rheumatology","author":"Cassidy JT","year":"2005"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar77"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.05.024"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/322547a0"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2863"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-7-6"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20019"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004271945"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12201","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T01:50:54Z","timestamp":1696211454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,16]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jop.12201"],"URL":"https:\/\/doi.org\/10.1111\/jop.12201","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,16]]}}}