{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:11:38Z","timestamp":1772665898224,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Matrix metalloproteases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s) are tissue\u2010remodeling enzymes that function during the remodeling process, such as in immune\u2010inflammatory diseases. Metalloprotease\u20102 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102) and metalloprotease\u20109 (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109) are gelatinases that degrade several types of extracellular matrix collagen. It is hypothesized that in temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) dysfunction, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression levels may be elevated. Therefore, the objective of this study is to determine the association of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression with temporomandibular joint dysfunction using an immunohistochemical approach to evaluate the joint disk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 45 human temporomandibular joint samples were collected, with 36 samples in the test group (patients with anterior disk displacement with reduction (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) and without reduction (<jats:italic>n<\/jats:italic>\u00a0=\u00a07)) and nine samples in the control group. The immunostaining of the <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> disks was statistically compared between the groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a statistically significant difference for the area of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 immunostaining between the control group and the displacement disks with reduction group (<jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>wR) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.048) and between the groups with disk displacement and without reduction (<jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>woR) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029). The expression of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 was significantly elevated in the <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>woR group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No statistically significant difference was found between the variable area of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 expression in the disk with and without disk displacement, as determined by immunohistochemical analysis. However, there was an elevation of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20102 expression in the disks of patients with displacement and without reduction (more severe alteration).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12213","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T05:12:16Z","timestamp":1406524336000},"page":"75-79","source":"Crossref","is-referenced-by-count":17,"title":["Immunohistochemical expression of matrix metalloprotease\u20102 and matrix metalloprotease\u20109 in the disks of patients with temporomandibular joint dysfunction"],"prefix":"10.1111","volume":"44","author":[{"given":"Luis Eduardo","family":"Almeida","sequence":"first","affiliation":[{"name":"Department of Oral Sciences Oral Surgery Marquette University School of Dentistry Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Caporal","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Catolica do Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane","family":"Ambros","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Catolica do Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Catolica do Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Noronha","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Catolica do Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosy","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula C","family":"Trevilatto","sequence":"additional","affiliation":[{"name":"Pontificia Universidade Catolica do Parana Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800030601"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(98)00107-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90051-9"},{"key":"e_1_2_5_5_1","first-page":"645","article-title":"Arthrography of the temporomandibular joint in patients with the TMJ pain\u2010dysfunction syndrome","volume":"61","author":"Wilkes C","year":"1978","journal-title":"Minutesn Med"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00015-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.815400"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00279-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400121"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21491"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.03.012"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300110.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2001.0634"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047888"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2007.11.010"},{"key":"e_1_2_5_17_1","first-page":"477","article-title":"Articular cartilage: tissue design and chondrocyte\u2010matrix interactions","volume":"47","author":"Buckwalter JA","year":"1998","journal-title":"Instr Course Lect"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(98)90868-0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90438-9"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2000.0306"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01012.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00803.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb03825.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2011.01351.x"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:51:23Z","timestamp":1696225883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,28]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jop.12213"],"URL":"https:\/\/doi.org\/10.1111\/jop.12213","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,28]]}}}