{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:58:01Z","timestamp":1791575881106,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100737"],"award-info":[{"award-number":["81100737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK2011762"],"award-info":[{"award-number":["BK2011762"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education","doi-asserted-by":"crossref","award":["20113234120003"],"award-info":[{"award-number":["20113234120003"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","award":["2014-37"],"award-info":[{"award-number":["2014-37"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The histone lysine\u2010specific demethylase (<jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1) is a key chromatin modifier mediating the demethylation of both H3K4me1\/me2 and H3K9 me1\/me2. Recently, its deregulation has been implicated in the initiation and progression of various cancers. The aim of this study was to investigate the expression pattern of <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 in tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) and determine its prognostic significance in predicting patients' prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 expression was examined by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and western blotting in three tongue cancer cell lines and by immunohistochemistry in 63 primary tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> specimens with detailed clinical, pathological, and follow\u2010up data. Its associations with various clinicopathological parameters, Ki\u201067 expression, and patients' survival were further assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upregulated <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 expression was observed in tongue cancer cells and a major fraction of tongue <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> samples. Overexpression of <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 significantly associated with tumor size (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0357), pathological grade (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0323), Ki\u201067 abundance (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0148), and reduced overall and disease\u2010free survival (Kaplan\u2013Meier analysis, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0351, 0.0479, respectively). The Cox regression survival analyses identified <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 as an important independent predictor for patients' overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that aberrant <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 overexpression associates with key clinicopathological features and unfavorable prognosis in patients with tongue cancer. <jats:styled-content style=\"fixed-case\">LSD<\/jats:styled-content>1 might play critical roles during tongue tumorigenesis and represent a novel biomarker and potential therapeutic target for this malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12220","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T14:20:54Z","timestamp":1405693254000},"page":"159-165","source":"Crossref","is-referenced-by-count":37,"title":["High expression of the histone demethylase <scp>LSD<\/scp>1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer"],"prefix":"10.1111","volume":"44","author":[{"given":"Chunping","family":"Yuan","sequence":"first","affiliation":[{"name":"Head Neck Cancer Center Institute of Stomatology Nanjing Medical University Jiangsu China"},{"name":"Department of Oral and Maxillofacial Surgery Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwu","family":"Li","sequence":"additional","affiliation":[{"name":"Head Neck Cancer Center Institute of Stomatology Nanjing Medical University Jiangsu China"},{"name":"Department of Oral and Maxillofacial Surgery Nanjing Medical University Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology School of Stomatology Nanjing Medical University Jiangsu 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