{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:28:41Z","timestamp":1761863321661},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mammary analog secretory carcinoma (<jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>) of the salivary gland has been recently described according to morphological, immunohistochemical, and molecular (<jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6\u2010<jats:styled-content style=\"fixed-case\">NTRK<\/jats:styled-content>3<\/jats:italic> translocation) similarities with the mammary secretory carcinoma. The most important differential diagnostic considerations of <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content> are low\u2010grade adenocarcinoma not otherwise specified (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>), cystadenocarcinoma, and acinic cell carcinoma (Aci<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>). These tumors may share an overlapping morphology with <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>, and additional immunohistochemical studies are required to reinforce the diagnosis. Mammaglobin, <jats:styled-content style=\"fixed-case\">GCDFP<\/jats:styled-content>\u201015, and p63 staining have been reported in <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>. Our study was designed to check the specificity of these antibodies in <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content> compared to other frequent tumors of salivary glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A series of 62 salivary gland tumors [10 <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>s, 5 adenocarcinomas <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> and 2 cystadenocarcinomas with <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content> features and without <jats:italic><jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6<\/jats:italic> rearrangement, one low\u2010grade cribriform cystadenocarcinoma (<jats:styled-content style=\"fixed-case\">LGCCC<\/jats:styled-content>), 9 AciCCs, 10 <jats:styled-content style=\"fixed-case\">MEC<\/jats:styled-content>s, 10 adenoid cystic carcinomas (Ade<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s), 5 polymorphous low\u2010grade adenocarcinomas (<jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>s), and 10 pleomorphic adenomas (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>s)] was analyzed by immunohistochemistry with mammaglobin, <jats:styled-content style=\"fixed-case\">GCDFP<\/jats:styled-content>\u201015, and p63 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positivity for mammaglobin was observed in all <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>s, cystadenocarcinomas, <jats:styled-content style=\"fixed-case\">LGCCC<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>s, in some adenocarcinomas <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PA<\/jats:styled-content>s, and <jats:styled-content style=\"fixed-case\">MEC<\/jats:styled-content>s, rarely in Aci<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s and never in Ade<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s. Positivity for <jats:styled-content style=\"fixed-case\">GCDFP<\/jats:styled-content>\u201015 was observed in most of the tumor types except in Ade<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>s. Interestingly, cytoplasmic positivity for p63 was observed in most of <jats:styled-content style=\"fixed-case\">MASC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">PLGA<\/jats:styled-content>s while rarely in adenocarcinomas <jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>s, and never in the other tumor types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study revealed the usefulness of mammaglobin and p63 cytoplasmic staining to define which tumors are worth to be screened for <jats:italic>ETV6<\/jats:italic> rearrangement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12226","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T14:21:30Z","timestamp":1405693290000},"page":"244-251","source":"Crossref","is-referenced-by-count":32,"title":["A comparative immunohistochemistry study of diagnostic tools in 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