{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:01:14Z","timestamp":1774976474198,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian Federal Agency"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic odontogenic tumors were evaluated by immunohistochemistry for cytokeratins, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138, \u03b2\u2010catenin, D2\u201040, Glut\u20101, <jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CD<\/jats:styled-content>10 and also by scanning electron microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>s, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138, \u03b2\u2010catenin, Glut\u20101, <jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic odontogenic tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic odontogenic tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal\/transitional cells was not uniform in the three tumors studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12234","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T06:09:05Z","timestamp":1406009345000},"page":"284-290","source":"Crossref","is-referenced-by-count":31,"title":["Ghost cells in pilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor: histological, immunohistochemical, and ultrastructural study"],"prefix":"10.1111","volume":"44","author":[{"given":"Alicia","family":"Rumayor","sequence":"first","affiliation":[{"name":"Oral Pathology Section Department of Oral Diagnosis Piracicaba Dental School University of Campinas\/UNICAMP Piracicaba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rom\u00e1n","family":"Carlos","sequence":"additional","affiliation":[{"name":"Pathology Division Centro Cl\u00ednico de Cabeza y Cuello\/Hospital Herrera Llerandi Guatemala City Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hern\u00e1n","family":"Molina Kirsch","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Guatemala City Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno A. 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