{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:05:20Z","timestamp":1762340720801,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences","doi-asserted-by":"crossref","award":["132\/252"],"award-info":[{"award-number":["132\/252"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In addition to ultraviolet radiation exposure, various molecular markers may differ between oral mucosal and cutaneous head and neck melanomas and lead to variations in their biologic behavior and prognosis. The aim of this study was to compare four such markers, namely microphthalmia transcription factor (<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>), P75, P53, and Ki\u201067 in malignant melanomas originating from the oral cavity and head and neck skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 19 oral mucosal and 23 head and neck cutaneous melanomas were subjected to immunohistochemical analysis using antibodies against <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>, P75, P53, and Ki\u201067. Statistical comparison of data was performed by <jats:italic>t<\/jats:italic>\u2010test and chi\u2010square analysis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) and Ki\u201067 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) were observed between oral mucosal and cutaneous melanomas. P75 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.80) and P53 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.76) did not differ significantly, between these locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to the results obtained in this study, the biological properties of cutaneous and mucosal melanoma differ, especially regarding <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> and Ki\u201067.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12235","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T06:09:15Z","timestamp":1406009355000},"page":"234-238","source":"Crossref","is-referenced-by-count":10,"title":["Immunohistochemical profile of oral mucosal and head and neck cutaneous melanoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Mojgan","family":"Alaeddini","sequence":"first","affiliation":[{"name":"Dental Research Centre Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahroo","family":"Etemad\u2010Moghadam","sequence":"additional","affiliation":[{"name":"Dental Research Centre Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00894.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.5.442"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90209-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.04.001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00085-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802404356"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90138-4"},{"key":"e_1_2_5_9_1","first-page":"155","article-title":"Oral and cutaneous melanoma: similarities and differences","volume":"2","author":"Moreira RN","year":"2010","journal-title":"J Clin Med Res"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.12.014"},{"key":"e_1_2_5_11_1","first-page":"783","article-title":"NRAS and BRAF mutation frequency in primary oral mucosal melanoma","volume":"26","author":"Buery RR","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21366"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01247462"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01053.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65172-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.06.010"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.4.466"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201009059"},{"key":"e_1_2_5_19_1","first-page":"5976","article-title":"Expression of mutant p53 in melanoma","volume":"51","author":"Stretch JR","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_5_20_1","first-page":"885","article-title":"Significance of P\u201053 antigen in malignant melanomas and naevi of the head and neck area","volume":"15","author":"Korabiowska M","year":"1995","journal-title":"Anticancer Res"},{"key":"e_1_2_5_21_1","first-page":"1062","article-title":"In vitro study on the effect of doxorubicin on the proliferation markers MCM3 and Ki\u201067","volume":"18","author":"Etemad\u2010Moghadam S","year":"2013","journal-title":"J BUON"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12312431"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2012.05.001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.05.005"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20785"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.861"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.008"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505059"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03269"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200410115"},{"key":"e_1_2_5_31_1","first-page":"2098","article-title":"The melanocyte\u2010specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma","volume":"62","author":"Selzer E","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_5_32_1","first-page":"5012","article-title":"DAS GUPTA TK. 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