{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:11:17Z","timestamp":1787724677811,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sardinia Regional Government"},{"name":"P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia"},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dataon structural alterations in human diabetic salivary glands are scanty and conflicting. The goal of this study is based on the evaluation of the morphological changes in submandibular glands of subjects with well\u2010controlled diabetes and without evident salivary malfunctions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Submandibular gland pieces from diabetic and non\u2010diabetic patients were fixed, dehydrated, and processed to obtain sections for light and electron microscopy. Randomly selected micrographs were statistically analyzed to reveal variations in serous acini.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphometrical evaluation allowed us to reveal significant changes such as enlargement of acinar and granule size, reduction of mitochondrial size, increased density of microbuds and protrusions along luminal membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results indicate that diabetes affects submandibular gland structure even when glandular function appears unaltered and suggest that morphological changes reflect functional changes chiefly regarding the secretory activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12238","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T05:39:23Z","timestamp":1409031563000},"page":"291-295","source":"Crossref","is-referenced-by-count":34,"title":["Diabetes causes morphological changes in human submandibular gland: a morphometric study"],"prefix":"10.1111","volume":"44","author":[{"given":"Maria Alberta","family":"Lilliu","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Solinas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Cossu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Loy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Quartu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Melis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Cagliari Monserrato CA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"33","article-title":"Evaluation of the relationship between type 2 diabetes and periodontal disease","volume":"32","author":"Awartani F","year":"2009","journal-title":"Odontostomatol Trop"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.300304.x"},{"key":"e_1_2_7_4_1","first-page":"262","article-title":"The relationship between periodontitis and diabetes: a brief review","volume":"68","author":"Moodley A","year":"2013","journal-title":"SADJ"},{"key":"e_1_2_7_5_1","first-page":"2","article-title":"Buccal alterations in diabetes mellitus","volume":"15","author":"Negrato CA","year":"2010","journal-title":"Diabetol Metab Syndr"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2007.40.1.029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(93)90025-T"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.028005373.x"},{"key":"e_1_2_7_9_1","first-page":"309","article-title":"Structural and functional salivary disorders in type 2 diabetic patients","volume":"1","author":"Carda C","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000028748.40917.6f"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004045-200504000-00009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2012_2077"},{"key":"e_1_2_7_13_1","first-page":"219","article-title":"Xerostomia and salivary levels of glucose and urea in patients with diabetes","volume":"33","author":"Ivanovski K","year":"2012","journal-title":"Prilozi"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432384"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90075-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00458557"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1008201"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90147-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01884.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01824.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01725.x"},{"key":"e_1_2_7_22_1","first-page":"53","article-title":"New findings on 3\u2010D microanatomy of cellular structures in human tissues and organs. An HRSEM study","volume":"51","author":"Riva A","year":"2007","journal-title":"Eur J Histochem"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diab.42.1.113","article-title":"Tissue kallikrein and tonin levels in submandibular glands of STZ\u2010induced diabetic rats and the effects of insulin","volume":"42","author":"Chan KM","year":"1993","journal-title":"Diabetes"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20236"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FMJ04004X6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-009-9159-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.01.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.112054"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01489.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.10815.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.12.002"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802629588"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/696215"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1153-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-011-0281-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070270105"},{"key":"e_1_2_7_37_1","first-page":"309","article-title":"Structural differences between alcoholic and diabetic parotid sialosis","volume":"10","author":"Carda C","year":"2005","journal-title":"Oral Med Pathol"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-009-0352-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00806.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0869-0_4"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:13:45Z","timestamp":1696238025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,26]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jop.12238"],"URL":"https:\/\/doi.org\/10.1111\/jop.12238","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,26]]}}}