{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:13:44Z","timestamp":1785827624701,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A portion of patients with recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high blood homocysteine level with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 273 <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients were measured and compared with the corresponding levels in 273 age\u2010 and sex\u2010matched healthy control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 57 (20.9%), 55 (20.1%), 13 (4.8%), and 7 (2.6%) <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients had deficiencies of hemoglobin (Men\u00a0&lt;\u00a013\u00a0g\/dl, Women\u00a0&lt;\u00a012\u00a0g\/dl), iron (&lt;60\u00a0\u03bcg\/dl), vitamin B12 (&lt;200\u00a0pg\/ml), and folic acid (&lt;4\u00a0ng\/ml), respectively. Moreover, 21 (7.7%) <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients had abnormally high blood homocysteine level. <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients had a significantly higher frequency of hemoglobin, iron, vitamin B12, or folic acid deficiency and of abnormally elevated blood homocysteine level than healthy control subjects (all <jats:italic>P<\/jats:italic>\u2010values\u00a0=\u00a00.000 except for folic acid <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.022). If 273 <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients were further divided into 32 patients with major\u2010typed <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> (Mj<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) and 241 patients with minor\u2010typed <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> (Mi<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>), we found that male Mj<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients had a significantly lower mean hemoglobin concentration than Mi<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.021), but Mj<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients had a significantly higher mean homocysteine level than Mi<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that there is a significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and abnormally high blood homocysteine level with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12241","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T06:10:02Z","timestamp":1406009402000},"page":"300-305","source":"Crossref","is-referenced-by-count":110,"title":["Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Andy","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dentistry School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Clinical Dentistry National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology School of Dentistry National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Jung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dentistry School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"National Taiwan University Hospital College of Medicine National Taiwan University Taipei 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