{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:44Z","timestamp":1740124424709,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T00:00:00Z","timestamp":1409011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province of China","doi-asserted-by":"crossref","award":["ZD201212"],"award-info":[{"award-number":["ZD201212"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Non\u2010syndromic orofacial clefts (<jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>) are the most common human craniofacial malformation in all worldwide populations. Recently, the <jats:italic>jumoji <\/jats:italic><jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\u2010rich interaction domain 2 (<jats:italic><jats:styled-content style=\"fixed-case\">JARID<\/jats:styled-content>2<\/jats:italic>) had been reported to be a novel candidate gene for non\u2010syndromic cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P). The <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s rs2076056, rs2237138 and rs2299043 in <jats:italic><jats:styled-content style=\"fixed-case\">JARID<\/jats:styled-content>2<\/jats:italic> were highly significant in Italian families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In the current research, a case\u2013control study was conducted to examine the association between these three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in a northern Chinese Han population. Genotyping of the three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were performed using <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>aPshot minisequencing technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Distribution of rs2237138 genotypes in <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P group was different from those in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), but significant results did not persist after Benjamini and Hochberg false discovery rate (<jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>) correction for multiple tests. Further logistic regression analysis showed that rs2237138 <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotypes were associated with decreased <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P susceptibility (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.34, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.13\u20130.84), compared with the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> wild\u2010type homozygote. For the haplotype <jats:styled-content style=\"fixed-case\">CGT<\/jats:styled-content>, a statistically difference was identified between the <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P group and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). And carriers of <jats:styled-content style=\"fixed-case\">GAT<\/jats:styled-content> haplotype were considered to be less frequent among cleft palate only group as compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). However, both of the haplotypes association did not remain statistically significant after Benjamini and Hochberg <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content> correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We got a weak association between these polymorphisms and <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in both single\u2010marker and haplotype analyses. Our data further strengthen the conclusion that <jats:italic><jats:styled-content style=\"fixed-case\">JARID<\/jats:styled-content>2<\/jats:italic> polymorphisms are associated with <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12244","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T06:16:18Z","timestamp":1409033778000},"page":"386-391","source":"Crossref","is-referenced-by-count":5,"title":["Association of <i><scp>JARID<\/scp>2<\/i> polymorphisms with non\u2010syndromic orofacial clefts in northern Chinese Han population"],"prefix":"10.1111","volume":"44","author":[{"given":"Yanru","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshu","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Stomatology The Fourth Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subao","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Stomatology Harbin Children's Hospital Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Harbin Children's Hospital Harbin 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