{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:58:31Z","timestamp":1789894711625,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Indian Council of Medical Research (ICMR), New Delhi, India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tongue cancer is the most common intra\u2010oral malignancy with a high rate of morbidity and mortality owing to its increased propensity for tumor invasion and metastasis. These processes require a controlled degradation of the extracellular matrix. Matrix Metalloproteinase\u20102 (MMP\u20102) and Matrix Metalloproteinase\u20109 (MMP\u20109) are known to be important regulators of matrix lysis and play a significant role in the metastasis of malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and objectives<\/jats:title><jats:p>To study the expression of MMP\u20102 and MMP\u20109 in the early stages of tongue squamous cell carcinoma and find the association between their expression and local recurrence, metastasis, and survival rates of the subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty\u2010nine tumor biopsy samples of tongue squamous cell carcinoma in T<jats:sub>1<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub> and T<jats:sub>2<\/jats:sub>N<jats:sub>0<\/jats:sub>M<jats:sub>0<\/jats:sub> stages were immunostained with MMP\u20102 and MMP\u20109 antibodies. The immunohistochemical expression was compared with the patient characteristics and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cytoplasmic expression of MMP\u20102 correlated with that of MMP\u20109 (<jats:italic>r\u00a0<\/jats:italic>=\u00a00.716, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Greater expression of MMP\u20102 and MMP\u20109 was observed in patients who subsequently developed local recurrence (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.044 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, respectively), regional and\/or distant metastasis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, respectively) of the tumor. Further, a higher expression of these biomarkers was associated with shorter survival. MMP\u20109 was found to have better specificity for local recurrence, metastasis and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results showed that these biomarkers may serve as indicators of a patient's risk potential for poor prognosis and presage the need for more aggressive treatment measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12245","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T08:18:32Z","timestamp":1410509912000},"page":"345-352","source":"Crossref","is-referenced-by-count":45,"title":["The role of MMP\u20102 and MMP\u20109 as prognostic markers in the early stages of tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"44","author":[{"given":"Manikkath","family":"Aparna","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Manipal College of Dental Sciences Manipal University Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Kasturba Medical College Manipal University Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayanarayana","family":"Kunhikatta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Manipal College of Pharmaceutical Sciences Manipal University Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Manipal College of Dental Sciences Manipal University Manipal Karnataka 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