{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:11:02Z","timestamp":1783642262254,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Background<\/jats:title>Of all oral precancerous conditions, Oral Submucous Fibrosis is of greater concern because of its disabling nature and relative greater chances of malignant transformation. This malignant transformation involves glycolytic pathways that can alter lactate dehydrogenase levels. Therefore the aim of this study was to estimate the LDH<\/jats:styled-content> levels in saliva and serum of subjects with OSMF<\/jats:styled-content> and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSMF<\/jats:styled-content> and the LDH<\/jats:styled-content> enzyme.<\/jats:p><\/jats:sec>Methods<\/jats:title>Sixty Subjects were recruited for this study and divided into two groups, 30 subjects with OSMF<\/jats:styled-content> (Group A<\/jats:styled-content>) and 30 healthy controls (Group B<\/jats:styled-content>). Venous blood and unstimulated whole saliva measuring 1\u00a0ml was collected from each of these evaluated for LDH<\/jats:styled-content> levels using the standard kit method. The data obtained were subjected to statistical analysis using the SPSS<\/jats:styled-content> software version 17.<\/jats:p><\/jats:sec>Results<\/jats:title>The average salivary LDH<\/jats:styled-content> value for Group A was 606.83\u00a0\u00b1\u00a060.09\u00a0U\/l and for Group B was 80.73\u00a0\u00b1\u00a020.06\u00a0U\/l. salivary LDH<\/jats:styled-content> was greater in group A than Group B and this was statistically significant. On comparing the serum and salivary LDH<\/jats:styled-content> in Group A with the clinical staging of OSMF<\/jats:styled-content>, the results were not statistically significant. Similarly no statistically significant relationship was found on comparing the serum and salivary LDH<\/jats:styled-content> in Group A (OSMF<\/jats:styled-content> subjects) with duration of habit.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study provides additional rationale for the role of salivary LDH<\/jats:styled-content> in the early diagnosis and prognosis of oral submucous fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12246","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T12:54:59Z","timestamp":1410785699000},"page":"449-452","source":"Crossref","is-referenced-by-count":32,"title":["Evaluation of lactate dehydrogenase enzyme activity in saliva and serum of oral submucous fibrosis patients"],"prefix":"10.1111","volume":"44","author":[{"given":"M.","family":"Sivaramakrishnan","sequence":"first","affiliation":[{"name":"Oral Pathology & Microbiology Indira Gandhi Institute of Dental Sciences Pondicherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sivapathasundharam","sequence":"additional","affiliation":[{"name":"Oral Pathology & Microbiology Meenakshi Ammal Dental College and Hospital Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jananni","sequence":"additional","affiliation":[{"name":"Periodontology Indira Gandhi Institute of Dental Sciences Pondicherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"783","article-title":"Prevalence of oral submucous fibrosis in the high natural radiation belt of Kerala, South India","volume":"70","author":"Rajendran R","year":"1992","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.04.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1968.tb02430.x"},{"key":"e_1_2_6_5_1","first-page":"632","article-title":"Total serum lactate dehydrogenase activity in acute Plasmodium falciparum malaria infections","volume":"46","author":"Garba IH","year":"2005","journal-title":"Singapore Med J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.22.51"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00625.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374315"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.33785"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2001.114710"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09081736"},{"key":"e_1_2_6_12_1","first-page":"329","article-title":"Hemoglobin levels in patients with oral submucous fibrosis","volume":"19","author":"Taneja L","year":"2007","journal-title":"JIAOMR"},{"key":"e_1_2_6_13_1","first-page":"509","article-title":"Lactate dehydrogenase isoenzyme patterns in leukoplakia, submucous fibrosis and carcinoma of the oral mucosa in south Indians","volume":"78","author":"Langvad E","year":"1970","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"e_1_2_6_14_1","first-page":"1","article-title":"Oral submucous fibrosis","volume":"7","author":"Rajendran R","year":"2003","journal-title":"JOMFP"},{"key":"e_1_2_6_15_1","first-page":"153","article-title":"Oral leukoplakia\u2014studies in enzyme histochemistry","volume":"48","author":"Shklar G","year":"1966","journal-title":"J Investig Dermatol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/0973-1482.92226","article-title":"Salivary lactate dehydrogenase levels in oral leukoplakia and oral squamous cell carcinoma: a biochemical and clinicopathological study","volume":"8","author":"Shetty SR","year":"2012","journal-title":"J Cancer Res Ther"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1965.120"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Salivary lactate dehydrogenase enzymes in oral lichen planus","volume":"2","author":"Rai B","year":"2008","journal-title":"Adv Med Dent Sci"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1990.tb00796.x"},{"key":"e_1_2_6_20_1","first-page":"291","article-title":"Enzyme and isoenzyme activity in patients with malignant tumors of the oral mucosa","volume":"38","author":"Bassalyk LS","year":"1992","journal-title":"Vopr Onkol"},{"key":"e_1_2_6_21_1","first-page":"613","article-title":"A comprehensive salivary analysis for oral cancer diagnosis","volume":"113","author":"Shpitzer T","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.3.9705014"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0904-2512.2004.00116.x"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12246","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12246","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:09:47Z","timestamp":1696234187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,15]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jop.12246"],"URL":"https:\/\/doi.org\/10.1111\/jop.12246","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,15]]}}}