{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:02:57Z","timestamp":1787169777027,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004799","name":"Australian Dental Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004799","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health of Oman"},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,7]]},"abstract":"\n Objectives<\/jats:title>\n \n Matrix metalloproteinases (\n MMP<\/jats:styled-content>\n s) are involved in both maintenance of healthy mucosa and mediation of several pathologies. Recently,\n MMP<\/jats:styled-content>\n s and their inhibitors have attracted attention as potential mediators of mucositis. We investigated tissue expression of\n MMP<\/jats:styled-content>\n \u20103 and\n MMP<\/jats:styled-content>\n \u20109 over time in a pre\u2010clinical model of irinotecan\u2010induced oral mucositis (\n OM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and methods<\/jats:title>\n \n Eighty\u2010one female Dark Agouti rats received either a single dose of irinotecan (200\u00a0mg\/kg) or vehicle control. Rats were killed at different time points over a 72\u2010h period and tongue mucosa examined histologically. Tissue expression of\n MMP<\/jats:styled-content>\n \u20103 and\n MMP<\/jats:styled-content>\n \u20109 was characterized by standard qualitative immunohistochemistry.\n <\/jats:p>\n <\/jats:sec>\n \n Results and discussion<\/jats:title>\n \n Epithelial thickness was reduced without any ulceration in the oral mucosa early after chemotherapy. Epithelial atrophy was associated with significant (\n P<\/jats:italic>\n \u00a0<\u00a00.05) upregulation of\n MMP<\/jats:styled-content>\n \u20103 and\n MMP<\/jats:styled-content>\n \u20109 in all layers of the oral epithelium. The increase of\n MMP<\/jats:styled-content>\n \u20103 was also significant (\n P<\/jats:italic>\n \u00a0<\u00a00.05) in lamina propria and submucosa. Most of changes in expression occurred early (1\u20136\u00a0h), coinciding with previously described upregulation of transcription factors and pro\u2010inflammatory cytokines in\n OM<\/jats:styled-content>\n . Tissue expression of\n MMP<\/jats:styled-content>\n \u20103 and\n MMP<\/jats:styled-content>\n \u20109 followed different patterns of change over time, suggesting involvement in various aspects of\n OM<\/jats:styled-content>\n pathophysiology.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings suggest vital roles played by\n MMP<\/jats:styled-content>\n \u20103 and\n MMP<\/jats:styled-content>\n \u20109 during\n OM<\/jats:styled-content>\n pathophysiology. Further research is required to investigate the role of other\n MMP<\/jats:styled-content>\n s and the naturally existing tissue inhibitors of\n MMP<\/jats:styled-content>\n s. Research should also be directed to investigate beneficial effects of\n MMP<\/jats:styled-content>\n s intervention therapies to prevent or reduce the severity of\n OM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12255","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T04:19:13Z","timestamp":1410495553000},"page":"459-467","source":"Crossref","is-referenced-by-count":35,"title":["Involvement of matrix metalloproteinases (\n MMP<\/scp>\n \u20103 and\n MMP<\/scp>\n \u20109) in the pathogenesis of irinotecan\u2010induced oral mucositis"],"prefix":"10.1111","volume":"44","author":[{"given":"Abdul R.","family":"Al\u2010Azri","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences School of Dentistry The University of Adelaide Adelaide SA Australia"},{"name":"Ministry of Health Muscat Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel 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