{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:16:54Z","timestamp":1790979414450,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Technology","award":["MOST-103-2314-B-040-019"],"award-info":[{"award-number":["MOST-103-2314-B-040-019"]}]},{"name":"Ministry of Science and Technology","award":["MOST-103-2632-B-040-001"],"award-info":[{"award-number":["MOST-103-2632-B-040-001"]}]},{"DOI":"10.13039\/501100008641","name":"Chung Shan Medical University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008641","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007632","name":"Changhua Christian Hospital","doi-asserted-by":"crossref","award":["CSMU-CCH-103-003"],"award-info":[{"award-number":["CSMU-CCH-103-003"]}],"id":[{"id":"10.13039\/501100007632","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changhua Christian Hospital Research","award":["101-CCH-IRP-90"],"award-info":[{"award-number":["101-CCH-IRP-90"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Background<\/jats:title>\n \n Naturally occurring agents, such as resveratrol, have been determined to benefit health. Numerous studies have demonstrated that resveratrol has antioxidative, cardioprotective, and neuroprotective properties. However, the effect of resveratrol exerts on the metastasis of oral cancer cells remains unclear. In this study, we investigated the effect the anti\u2010invasive activity of resveratrol on a human oral cancer cell line (\n SCC<\/jats:styled-content>\n \u20109)\n in vitro<\/jats:italic>\n and the underlying mechanisms.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cell viability was examined by\n MTT<\/jats:styled-content>\n assay, whereas cell motility was measured by migration and wound\u2010healing assays. Zymography, reverse\u2010transcriptase polymerase chain reaction (\n PCR<\/jats:styled-content>\n ), and promoter assays confirmed the inhibitory effects of resveratrol on matrix metalloproteinase\u20109 (\n MMP<\/jats:styled-content>\n \u20109) expression in oral cancer cells.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We established that various concentrations (0\u2013100\u00a0\u03bcM) of resveratrol inhibited the 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate (\n TPA<\/jats:styled-content>\n )\u2010induced migration capacities of\n SCC<\/jats:styled-content>\n \u20109 cells and caused no cytotoxic effects. Zymography and Western blot analyses suggested that resveratrol inhibited\n TPA<\/jats:styled-content>\n \u2010induced\n MMP<\/jats:styled-content>\n \u20109 gelatinolytic activity and protein expression. In addition, the results indicated that resveratrol inhibited the phosphorylation of c\u2010Jun N\u2010terminal kinase (\n JNK<\/jats:styled-content>\n )1\/2 and extracellular\u2010signal\u2010regulated kinase (\n ERK<\/jats:styled-content>\n )1\/2 involved in downregulating protein expression and the transcription of\n MMP<\/jats:styled-content>\n \u20109.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In summary, resveratrol inhibited\n MMP<\/jats:styled-content>\n \u20109 expression and oral cancer cell metastasis by downregulating\n JNK<\/jats:styled-content>\n 1\/2 and\n ERK<\/jats:styled-content>\n 1\/2 signals pathways and, thus, exerts beneficial effects in chemoprevention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12288","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T07:51:13Z","timestamp":1416210673000},"page":"699-706","source":"Crossref","is-referenced-by-count":57,"title":["Resveratrol suppresses\n TPA<\/scp>\n \u2010induced matrix metalloproteinase\u20109 expression through the inhibition of\n MAPK<\/scp>\n pathways in oral cancer cells"],"prefix":"10.1111","volume":"44","author":[{"given":"Feng\u2010Yan","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Emergency Medicine Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsien","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung 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