{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:48:55Z","timestamp":1792100935759,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25861768"],"award-info":[{"award-number":["25861768"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004009","name":"Iwadare Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>), an autoimmune blistering disease, is mainly mediated by autoantibodies against desmoglein (Dsg) 3. However, no attention has been paid to IgG subclasses of the autoantibodies against Dsg3 in the diagnostic procedure for <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. Thus, our aim in this study was to investigate whether Dsg3 and any of IgG subclasses are immunohistochemically colocalized in tissue sections of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Serial sections cut from formalin\u2010fixed paraffin blocks of biopsy specimens of 9 <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> cases and those of normal buccal mucosa surgically removed for fibro\u2010epithelial polyps were comparatively examined for immunohistochemical localizations for Dsg3, IgG4, and IgG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dsg3 was demonstrated in a dot\u2010like pattern on the cell border and in the cytoplasm of the whole epithelial layer in both normal and <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> specimens, while its staining was irregular among floating epithelial sheets of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>. IgG4 was also demonstrated in a punctuated fashion on the cell border among floating epithelial sheets, which was nearly identical to the immunohistochemical profile of Dsg3. In addition to being detected in the epithelial part, IgG4 signals were prominently localized in plasma cells scattered in the granulation tissue, where ratios of IgG4\u2010positive (+) plasma cells to IgG+ cells were extraordinarily higher (mean 28%) than those in normal mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings confirmed for the first time that autoantibodies against Dsg3 are mainly composed of IgG4 in oral <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> and that the combined immunohistochemistry for Dsg3 and IgG4 can be a valuable aid in confirming a histopathological diagnosis of <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12290","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T12:51:24Z","timestamp":1416228684000},"page":"850-856","source":"Crossref","is-referenced-by-count":8,"title":["Simultaneous immunolocalization of desmoglein 3 and IgG4 in oral pemphigus vulgaris: IgG4 predominant autoantibodies in its pathogenesis"],"prefix":"10.1111","volume":"44","author":[{"given":"Tatsuya","family":"Ab\u00e9","sequence":"first","affiliation":[{"name":"Division of Oral Pathology Department of Tissue Regeneration and Reconstruction Niigata University Graduate School of Medical and Dental Sciences Chuo\u2010ku Niigata Japan"},{"name":"Oral Pathology Section Department of Surgical Pathology Niigata University Hospital Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Surgical Pathology Niigata University Hospital Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzah","family":"Babkair","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology Department of Tissue Regeneration 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