{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T17:29:41Z","timestamp":1706894981040},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione ANDI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human papilloma virus oral infection can be related to several factors including <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection, cigarette smoking, marijuana consumption and number of sexual partners. We conducted a study on oral <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence and clearance among the hosts of the San Patrignano community, a population considered at \u201chigh\u2010risk\u201d for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> due to their previous habits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From March 2007 to September 2010 all subjects were submitted to oropharyngeal brushing and saliva collection at baseline, after 6, 12 and 48\u00a0months (for subjects <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive at baseline). Samples were analyzed to detect <jats:styled-content style=\"fixed-case\">HPV DNA<\/jats:styled-content> and virus genotypes. The correlation between <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence and demographic, behavioral or immunological characteristics was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 194 subjects, 30 (15%) were <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive with 25 (13%) high\u2010risk (HR)\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> at baseline brushing. At 12\u00a0months <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection was cleared in all cases. However at 48\u00a0months <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> was newly detected in 33% of subjects. A correlation between time spent in the community and increase in the ratio of \u201clow\u2010risk\u201d (<jats:styled-content style=\"fixed-case\">LR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> was observed. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection was not associated with age, gender, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, alcohol and\/or drug exposure, number of years spent in community, sex with drug\u2010addicts and condom use. Only <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content> under antiretroviral treatment was inversely correlated with the risk of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 1\u00a0year a complete <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance was observed which could be related to adoption of healthier lifestyles of participants. New <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections were detected even in the absence of the recognized and declared risky behavioral factors, suggesting a re\u2010expression from a latent infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12291","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T12:51:52Z","timestamp":1416228712000},"page":"728-733","source":"Crossref","is-referenced-by-count":3,"title":["Oral prevalence and clearance of oncogenic human papilloma virus in a rehabilitation community for substance abusers in Italy: a case of behavioral correction?"],"prefix":"10.1111","volume":"44","author":[{"given":"Davide B.","family":"Pugliese","sequence":"first","affiliation":[{"name":"Odontostomathology Service Centro Medico San Patrignano Coriano Rimini 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