{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:46Z","timestamp":1740124426842,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EVO funds of Kuopio University Hospital"},{"name":"The Spearhead Funds of the University of Eastern Finland\/the Cancer Center of Eastern Finland,"},{"name":"Sigrid Juselius Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral lichen planus (OLP) is an immune\u2010mediated mucosal disease of unclear etiology and of unresolved pathogenesis. Hyaluronan (HA) is an extracellular matrix glycosaminoglycan involved in inflammation and tumor progression. However, its presence in OLP has not been reported. We therefore aimed to study the immunohistochemical expression of HA, its receptor CD44, hyaluronan synthases (HAS1\u20103), and hyaluronidases (HYAL1\u20102) in OLP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The presence of HA, CD44, HAS1\u20103, and HYAL1\u20102 was studied by immunohistochemical methods in 55 OLP and 23 control oral mucosal specimens (CTR). The localization, intensity, and differences of the epithelial expression between OLP and CTRs were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HA and CD44 were found on cell membranes in the epithelial basal and intermediate layers in CTR and OLP specimens. The HA staining intensity was stronger in the basal layer of the epithelium in OLP than in CTRs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). HAS1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and HAS2 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) showed stronger staining in the basal and weaker staining in the superficial (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) epithelial layers in OLP than in CTRs. The immunostaining of HAS3 was low in both OLP and CTRs. Positive HYAL1 and HYAL2 staining were mainly found in the basal and intermediate epithelial layers, and their intensities were significantly increased in OLP, except HYAL 2 in the intermediate epithelial layer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HA, HAS1\u20102, and HYAL1\u20102 have altered expression in OLP compared to CTRs and may therefore have a role in OLP pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12294","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T10:40:20Z","timestamp":1416912020000},"page":"401-409","source":"Crossref","is-referenced-by-count":5,"title":["Altered expression of hyaluronan, HAS1\u20102, and HYAL1\u20102 in oral lichen planus"],"prefix":"10.1111","volume":"44","author":[{"given":"Maria","family":"Siponen","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Oral Medicine Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Department of Oral and Maxillofacial Diseases Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arja","family":"Kullaa","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Oral Medicine Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Educational Dental Clinic Health Center of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Medical Informatics and Statistics Research Group Faculty of Medicine University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuula","family":"Salo","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Oral Medicine Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu University Hospital Oulu Finland"},{"name":"Institute of Dentistry University of Helsinki Helsinki Finland"},{"name":"Graduate Program in Estomatopatologia Piracicaba Dental School University of Campinas Piracicaba\u2010S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanna","family":"Pasonen\u2010Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine School of Medicine Faculty of Health Sciences University of Eastern Finland Kuopio 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