{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:45:04Z","timestamp":1772714704872,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Temporomandibular joint (TMJ<\/jats:styled-content>) internal derangement (ID<\/jats:styled-content>) is one of the most common form of temporomandibular disorders. There is evidence showing the increased expression of matrix metalloproteinases (MMP<\/jats:styled-content>s) in the cells from degenerated TMJ<\/jats:styled-content> disc. ADAMTS<\/jats:styled-content> are a large family of metalloproteases which are responsible for proteoglycans degradation. The present study aimed to evaluate ADAMTS<\/jats:styled-content>\u20104 and ADAMTS<\/jats:styled-content>\u20105 immunohistochemical expression in human TMJ<\/jats:styled-content> discs from patients affected by ID<\/jats:styled-content>, and to find out if there is any correlation with the degree of histopathological changes. Eighteen temporomandibular displaced disc specimens and sixteen TMJ<\/jats:styled-content> disc control were used for the present study. Specimens were immunohistochemically processed and ADAMTS<\/jats:styled-content>\u20104 and ADAMTS<\/jats:styled-content>\u20105 expression were obtained respectively for the anterior (AB<\/jats:styled-content>), intermediate (IB<\/jats:styled-content>) and posterior (PB<\/jats:styled-content>) bands and compared to the histopathological degeneration score (HDS<\/jats:styled-content>). Immunoreactivity for ADAMTS<\/jats:styled-content>\u20104 and \u20105, was observed in both not degenerated and degenerated human TMJ<\/jats:styled-content> discs. Both the percentage of ADAMTS<\/jats:styled-content>\u20104 and \u20105 immunostained cells (ES<\/jats:styled-content>) and the intensity of staining (IS<\/jats:styled-content>) were significantly greater in affected specimens compared with those in control discs. The ADAMTS<\/jats:styled-content>\u20105 ES<\/jats:styled-content> and IS<\/jats:styled-content> of the 3 bands of the disc correlated to the TMJ<\/jats:styled-content> disc HDS<\/jats:styled-content> (0.001\u00a0< P<\/jats:italic>\u00a0<\u00a00.05), on the other hand only AB<\/jats:styled-content> and IB<\/jats:styled-content>, ADAMTS<\/jats:styled-content>\u20104 immunostaining scores correlated to HDS<\/jats:styled-content>. According to these findings it can be assumed in that the more histopathological changes in the disc are detected, the higher levels of ADAMTS<\/jats:styled-content> are produced. This in turn can lead to ECM<\/jats:styled-content> breakdown and in turn to a more advanced disc displacement.<\/jats:p>","DOI":"10.1111\/jop.12295","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T23:26:01Z","timestamp":1418081161000},"page":"870-875","source":"Crossref","is-referenced-by-count":12,"title":["ADAMTS<\/scp>\u20104 and ADAMTS<\/scp>\u20105 expression in human temporomandibular joint discs with internal derangement, correlates with degeneration"],"prefix":"10.1111","volume":"44","author":[{"given":"Rosalia","family":"Leonardi","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Orofacial Pain University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Crimi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery University of Messina Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Eduardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Marquette University Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pannone","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Institute of Pathology and Cytopathology University of Foggia Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Medical Sciences Anatomy Section University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Castorina","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Medical Sciences Anatomy Section University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugurel Constantin","family":"Rusu","sequence":"additional","affiliation":[{"name":"Division of Anatomy Faculty of Dental Medicine \u2018Carol Davila\u2019 University of Medicine and Pharmacy Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Loreto","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Medical Sciences Anatomy Section University of Catania Catania 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